An epigenetic approach to correcting involutional skin changes

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Abstract

The study of aging mechanisms has remained an important area of scientific research for many years. Currently, particular attention is being paid to epigenetic mechanisms of aging. Current knowledge of the epigenetic aspects of age-related skin changes opens up extensive opportunities for the development of therapeutic tools that target the cellular and molecular patterns of skin aging. Epicellin, a flavonoid from Ampelopsis grossedentata, exhibits antioxidant, anti-inflammatory, antibacterial, and antitumor activity. It reactivates youth genes and significantly eliminates signs of skin aging caused by epigenetic changes by inhibiting DNA methyltransferase 1, an enzyme that plays a key role in age-associated pathological DNA methylation.

About the authors

L. S. Kruglova

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation

Author for correspondence.
Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265

Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Rector, Head of the Department of Dermatovenereology and Cosmetology

Russian Federation, Moscow

A. S. Polonskaya

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation

Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0001-6888-4760

Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology

Russian Federation, Moscow

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