Retrospective cohort study of the association between previous syphilis and the risk of developing acute cerebrovascular accident
- Authors: Novikov Y.A.1, Zadorozhnaya A.V.2, Zubareva E.Y.3, Pravdina O.V.3, Radul E.V.3, Filippov S.O.1
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Affiliations:
- Clinical Dermatovenerological Dispensary
- Regional Clinical Hospital
- Omsk State Medical University
- Issue: Vol 32, No 5 (2025)
- Pages: 74-79
- Section: Original articles
- URL: https://journals.rcsi.science/2073-4034/article/view/316495
- DOI: https://doi.org/10.18565/pharmateca.2025.5.74-79
- ID: 316495
Cite item
Abstract
Background: The possibility of vascular damage in syphilis has been considered by scientists for a long time. Currently, the list of mechanisms of influence of Treponema pallidum both on the endothelium in general and on the blood-brain barrier in particular has been significantly expanded. However, the question of the consequences of syphilis for the human body remains debatable even in the case of fully administered specific therapy.
Objective: Retrospective cohort study to confirm the relationship between syphilis and the risk of developing acute cerebrovascular accident.
Materials and methods: A retrospective cohort study of the medical records of 2022 patients hospitalized with suspected acute cerebrovascular accident (ACVA) in 2017–2018 was conducted. The study groups were divided into the following: the main group (n=36) – patients with a history of confirmed syphilis, the comparison group (n=35) – patients without syphilis. Clinical, instrumental (MSCT, MRI) and laboratory research methods (ELISA, CP) were used.
Results: In the main group, ACVA developed 19 years earlier (mean age 51.8±10.5 years). The incidence of ischemic stroke was comparable (66% versus 68.5%), but patients with syphilis more often had combined arterial lesions (12.5% versus 0%) and papilledema (65.3% versus 22%).
Conclusion: Previous syphilis can increase the risk of early development of stroke and contribute to more severe neurological complications, which requires the development of secondary prevention measures.
Full Text
##article.viewOnOriginalSite##About the authors
Yury A. Novikov
Clinical Dermatovenerological Dispensary
Author for correspondence.
Email: skinandven@omsk-osma.ru
ORCID iD: 0000-0003-0391-5372
Dr. Sci. (Med.), Associate Professor, Chief Physician; Head of the Department of Dermatovenereology and Cosmetology
Russian Federation, OmskAnna V. Zadorozhnaya
Regional Clinical Hospital
Email: skinandven@omsk-osma.ru
ORCID iD: 0000-0002-0216-1831
Russian Federation, Omsk
Elena Yu. Zubareva
Omsk State Medical University
Email: skinandven@omsk-osma.ru
ORCID iD: 0000-0003-1156-682X
Department of Dermatovenereology and Cosmetology
Russian Federation, OmskOlga V. Pravdina
Omsk State Medical University
Email: skinandven@omsk-osma.ru
ORCID iD: 0000-0002-1804-6248
Department of Dermatovenereology and Cosmetology
Russian Federation, OmskElena V. Radul
Omsk State Medical University
Email: skinandven@omsk-osma.ru
ORCID iD: 0000-0002-9395-9792
Department of Dermatovenereology and Cosmetology
Russian Federation, OmskSergey O. Filippov
Clinical Dermatovenerological Dispensary
Email: skinandven@omsk-osma.ru
Russian Federation, Omsk
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