Successful Treatment Of The Patient With Advanced Testic Cancer


Cite item

Full Text

Abstract

Testicular cancer is a rare oncourological disease. Of great significance is the fact of the disease onset precisely at the age when men are planning their future life: education, family, etc. According to current clinical guidelines, the treatment of this disease should be complex, including surgical treatment, polychemotherapy and external beam radiation therapy, which leads to a cure in 90% of cases.
In the presented clinical case, a 25-year-old patient was diagnosed with right testicular cancer stage III, T2N3M1S0 [PUL]. However, despite the significant initial prevalence of the pathological process, as well as the detection of a single retroperitoneal metastasis in the pancreas two years after the last stage of surgical treatment, the applied multi-stage tactics of complex treatment of the patient allowed not only removing the tumor and metastases, but also rehabilitating the patient socially.

About the authors

Yulia Aleksandrovna Stepanova

A.V. Vishnevsky National Medical Research Center of Surgery
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: stepanovaua@mail.ru
ORCID iD: 0000-0002-2348-4963
SPIN-code: 1288-6141

MD, Professor

Academic Secretary of A.V. Vishnevsky National Medical Research Center of Surgery

prof. of Surgery and Surgical Technologies Department of A.I. Evdokimov Moscow State University of Medicine and Dentistry 

Russian Federation, Moscow, Russian Federation

Alexander Anatolyevich Gritskevich

A.V. Vishnevsky National Medical Research Center of Surgery

Email: grekaa@mail.ru
ORCID iD: 0000-0002-5160-925X
SPIN-code: 2128-7536

M.D., Head of Urology Department

Moscow, Russian Federation

Vardan Arshavirovich Oganyan

A.V. Vishnevsky National Medical Research Center of Surgery

Email: grekaa@mail.ru
ORCID iD: 0000-0002-2059-8703

Junior Researcher of Urology Department

Russian Federation, Moscow, Russian Federation

Dmitry Valerievich Kalinin

A.V. Vishnevsky National Medical Research Center of Surgery

Author for correspondence.
Email: grekaa@mail.ru
ORCID iD: 0000-0001-6247-9481
SPIN-code: 5563-5376

Ph.D., Head of Pathological anatomy department

Russian Federation, Moscow, Russian Federation

References

  1. Richie JP. Neoplasms of the testis, in Walsh P.C. et al. (eds). Campbell’s Urology. 7th ed. Philadelphia: Saunders. 1997; 2411–2452. (in Russ.)
  2. Schottenfeld D, Warshauer ME, Sherlock S, Zauber AG, Leder M, Payne R. The epidemiology of testicular cancer in young adults. Am J Epidemiol. 1980; 112(2): 232–246.
  3. Isargapov RM, Gorbachev AL, Khakimov VG, Evseev DS. Results of the combined treatment of patients diagnosed with testicular cancer at the Sokod State Budgetary Healthcare Institution. Vestnik meditsinskogo instituta «REAVIZ». 2018; 4: 65-69. (in Russ.)
  4. Stephenson A, Eggener SE, Bass EB, Chelnick DM, Daneshmand S, Feldman D. Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline. J Urol. 2019; 202(2): 272-281. doi: 10.1097/JU.0000000000000318.
  5. Testicular cancer (C62). ONCOLOGY.RU. http://www.oncology.ru/specialist/epidemiology/malignant/C62/ (date of the application 07.05.2022) (in Russ.)
  6. Westergaard T, Olsen JH, Frisch M, Kroman N, Nielsen JW, Melbye M. Cancer risk in fathers and brothers of testicular cancer patients in Denmark. A population-based study. Int J Cancer. 1996; 66(5): 627-631. doi: 10.1002/(SICI)1097-0215(19960529)66:5<627::AID-IJC8>3.0.CO;2-V.
  7. Sonneveld DJ, Sleijfer DT, Schrafford Koops H, Sijmons RH, van der Graaf WT, Sluiter W, Hoekstra HJ. Familial testicular cancer in a single-centre population. Eur J Cancer. 1999; 35(9): 1368-1373. doi: 10.1016/s0959-8049(99)00140-9.
  8. Cook MB, Akre O, Forman D, Madigan MP, Richiardi L, McGlynn KA. A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the mother. Int. J. Epidemiol. 2009; 38: 1532–1542. doi: 10.1093/ije/dyp287
  9. Cook MB, Akre O, Forman D, Madigan MP, Richiardi L, McGlynn KA. A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son. Int J Epidemiol. 2010; 39(6): 1605-1618. doi: 10.1093/ije/dyq120.
  10. Clinical oncourology. Ed. by prof. B.P. Matveeva. M.: ABV-press, 2011: 791–795. (in Russ.)
  11. McGlynn KA, Devesa SS, Sigurdson AJ, Brown LM, Tsao L, Tarone RE. Trends in the incidence of testicular germ cell tumors in the United States. Cancer. 2003; 97(1): 63-70. doi: 10.1002/cncr.11054.
  12. Dijkstra SS, Witjes JA. A patient with bilateral testicular cancer. Ned Tijdschr Geneeskd. 2012; 156(11): A3392.
  13. Shin YS, Kim HJ. Current management of testicular cancer. Korean J Urol. 2013; 54(1): 2-10. doi: 10.4111/kju.2013.54.1.2.
  14. Germà-Lluch JR, Garcia del Muro X, Maroto P, Paz-Ares L, Arranz JA, Gumà J, Alba E, Sastre J, Aparicio J, Fernández A, Barnadas A, Terrassa J, Sáenz A, Almenar D, López-Brea M, Climent MA, Sánchez MA, Lasso de la Vega R, Berenguer G, Pérez X. Spanish Germ-Cell Cancer Group (GG). Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish Germ-Cell Cancer Group (GG). Eur Urol. 2002; 42(6): 553-562. doi: 10.1016/s0302-2838(02)00439-6.
  15. Shaw J. Diagnosis and Treatment of Testicular Cancer. American Family Physician. 2008; 77(4): 469-474.
  16. Shin YS, Kim HJ. Current management of testicular cancer. Korean J Urol. 2013; 54(1): 2-10. doi: 10.4111/kju.2013.54.1.2.
  17. Porfiri E, Stevenson R, Patel P, Viney R, Hutton P, Guest P, Burgess L. Guidelines for the Management of Testicular Cancer. West Midlands Expert Advisory Group for Urological Cancer. 2016. https://www.england.nhs.uk/mids-east/wp-content/uploads/sites/7/2018/05/guidelines-for-the-management-of-testicular-cancer.pdf
  18. Baird DC, Meyers GJ, Hu JS. Testicular Cancer: Diagnosis and Treatment. Am Fam Physician. 2018; 97(4): 261-268.
  19. McGlynn K.A., Cook M.B. Etiologic factors in testicular germ-cell tumors. Future Oncol. 2009 Nov; 5(9): 1389-13402. doi: 10.2217/fon.09.116
  20. Minciuna V, Crețu O, Spînu D, Marcu D, Bratu O. The Impact of Testicular Cancer on Fertility - Literature Review. Medicina Moderna - Modern Medicine. 2017; 24(4): 195-198. doi: 10.31689/rmm.2017.24.4.195
  21. Záková J, Lousová E, Ventruba P, Crha I, Pochopová H, Vinklárková J, Tesařová E, Nussir M. Sperm cryopreservation before testicular cancer treatment and its subsequent utilization for the treatment of infertility. ScientificWorldJournal. 2014 Jan 22; 2014: 575978. doi: 10.1155/2014/575978.
  22. Gilbert K, Nangia AK, Dupree JM, Smith JF, Mehta A. Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology? Urol Oncol. 2018; 36(3): 92.e1-92.e9. doi: 10.1016/j.urolonc.2017.11.002.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).