电邮这篇文章 Lornoxicam effect on emostasis in patients after craniotomy in early postoperative period
- 作者: Imaev A.1, Dolmatova E.2, Solenkova A.1, Moshkin A.1, Kulikov A.1, Lubnin A.1
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隶属关系:
- FSBI “Burdenko Scientific Research Neurosurgery Institute”
- Massachusetts General Hospital
- 期: 卷 9, 编号 3 (2015)
- 页面: 5-13
- 栏目: Articles
- URL: https://journals.rcsi.science/1993-6508/article/view/36249
- DOI: https://doi.org/10.17816/ра.v9i3.36249
- ID: 36249
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Lornoxicam, one of NSAIDs, is considered as effective medication for postoperative analgesia. One of the well-known side effects of NSAIDs is hypocoagulation which can be dangerous in neurosurgery. The goal of this study was assessment of lornoxicam influence on hemostasis in perioperative period. Materials and methods: 20 patients after craniotomy for tumor removal were enrolled in the study. Lornoxicam was used in “scheduled” dosing mode: 8 mg during anesthesia induction, followed by 8 mg each 8 hours for 3 days. TEG and PFA analysis were used for hemostasis assessment on 0,1,3 and 5 days of perioperative period. Results: We didn't detected hypocoagulation in patients during the study. Moreover we noted a tendency for hypercoagulation in early postoperative period. It can be explained by hemostasis activation by intraoperative trauma. This effect is seemed more significant than hypocoagulation effect of NSAID in our group of patients. Conclusion: “Scheduled” dosing of lornoxicam don't inhibit hemostasis in neurosurgical patients.
作者简介
Aleksandr Imaev
FSBI “Burdenko Scientific Research Neurosurgery Institute”
Email: aimaev@nsi.ru
125047, Moscow
E. Dolmatova
Massachusetts General HospitalBoston, MA 02114-2622, USA
A. Solenkova
FSBI “Burdenko Scientific Research Neurosurgery Institute”125047, Moscow
A. Moshkin
FSBI “Burdenko Scientific Research Neurosurgery Institute”125047, Moscow
A. Kulikov
FSBI “Burdenko Scientific Research Neurosurgery Institute”125047, Moscow
A. Lubnin
FSBI “Burdenko Scientific Research Neurosurgery Institute”125047, Moscow
参考
- Овечкин А.М. Послеоперационный болевой синдром: клинико-патофизиологическое значение и перспектива направления терапии. Consilium Medicum. 2005; 6.
- Петрова В.В., Осипова Н.А., Береснев В.А. и др. Ксефокам (лорноксикам) как средство профилактики и лечения послеоперационного болевого синдрома среди других НПВП. Анестезиол. и реаниматол. 2005; 5: 39-43.
- Hansen M.S., Brennum J., Moltke F.B., Dahl J.B. Pain treatment after craniotomy: where is the (procedure-specific) evidence? A qualitative systematic review. Eur J Anaesthesiol. 2011; 28: 821-829.
- Авксентюк А.В. Лорноксикам - новый НПВП класса оксикамов с сильным анальгетическим эффектом. Обзор литературы. Боль и ее лечение. 1999; 10: 9.
- Norholt S. E., Sindet-Pedersen S., Bugge C. et al. A randomized, double-blind, placebo-controlled, dose-response study of the analgesic effect of lornoxicam after surgical removal of mandibular third molars. J ClinPharmacol. 1995; 35: 606-614.
- Rahimi S.Y., Vender J.R., Macomson S.D. et al. Postoperative pain management after craniotomy: evaluation and cost analysis. Neurosurgery. 2006; 59: 852-857.
- Ксефокам (лорноксикам). Новый обезболивающий противовоспалительный препарат. Монография по продукту. М., 1998.
- Palmer J.D., Sparrow О.С., Ianotti F. Postoperative haematoma: a five-year survey and identification of avoidable risk factors. Neurosurgery. 1994; 35: 1061-1065.
- Иванец Н.Н., Винникова М.А. Опыт применения Ксефокама (лорноксикама) для купирования болевого синдрома у больных героиновой наркоманией. Вопросы наркологии. 2001; 4.
- Кузнецов А.К., Теркулов Р.А. Терапия болевого синдрома у больных опийной наркоманией. Издание: Новосибирский областной наркологический диспансер. 2000.
- Karaman Y., Kebabci E., Gurkan A. The preemptive analgesic effect of lornoxicam in pacients undergoing major abdominal surgery: a randomised controlled study. Int J Surg. 2008; 6: 193-196.
- Rosenov D.E., Albrechtsen M., and Stolke D. A comparison of patient-controlled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery. Anesth. Analg. 1998; 86: 1045-1050.
- Talke P.O., Gelb A.W. Postcraniotomy pain remains a real headache! Eur. J. Anesthesiol. 2005; 22: 325-327.
- Umamaheswara Rao G.S., Gelb A.W. To use or not to use: the dilemma of NSAIDs and craniotomy. Eur J Anaesthesiol. 2009; 26: 625-626.
- Bala I., Gupta B., Bhardwaj N. et al. Effect of scalp bloc on postoperative pain relief in craniotomy patients. Anaesth Intensive Care. 2006; 34: 224-227.
- Gottschalk A., Berkow L.C., Stevens R.D. et al. Prospective evaluation of pain and analgesic use following major elective intracranial surgery. J. Neurosurg. 2007; 106: 210-216.
- Dolmatova E.V., Imaev A.A., Lubnin A.Y. “Scheduled” dosing of lornoxicam provides analgesia superior to that provided by “on request” dosing following craniotomy. Eur J Anaesthesiol. 2009; 26: 633-635.
