Neuropathic pain treatment with xenon
- 作者: Khinovker V.1,2, Veselova O.1,2,3, Khinovker E.2, Koryachkin V.3
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隶属关系:
- Federal Siberian Research Clinical Centre
- Krasnoyarsk State Medical University
- Saint-Petersburg State Pediatric Medical University
- 期: 卷 16, 编号 2 (2022)
- 页面: 151-159
- 栏目: Original articles
- URL: https://journals.rcsi.science/1993-6508/article/view/108649
- DOI: https://doi.org/10.17816/1993-6508-2022-16-1-151-159
- ID: 108649
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详细
THE AIM: This study aimed to evaluate the effects of xenon on neuropathic pain during parapulmonal injections in the rat model. Xenon is a drug for inhalation anesthesia that is assumed to have an analgesic effect when administered parapulmonary (similar to nitrous oxide and cyclopropane) and can later be used as an alternative analgesic drug in patients with pain syndrome that is not controlled by standard methods.
MATERIALS AND METHODS: The experiment used in vivo model of neuropathic pain by Bennet and Xie (1988) on rats with sciatic nerve transection. Additionally, a special scoring was adopted based on known behavioral changes of experimental animals (self-harm of limbs, neatness, activity, and bedding conditions). The control group was subcutaneously administered air daily for 5 days, and the experimental group received medical xenon at 40 ml/kg. The pain was assessed with the subcutaneous introduction of air and xenon in the experimental and control groups.
RESULTS: Study results revealed that rats from the experimental group (xenon) showed fewer signs of neuropathic pain syndrome development compared to the control group (air).
CONCLUSION: Therefore, parapulmonal injections of xenon showed a high analgesia effect in animal models of chronic neuropathic pain.
作者简介
Vladimir Khinovker
Federal Siberian Research Clinical Centre; Krasnoyarsk State Medical University
编辑信件的主要联系方式.
Email: vhinov@hotmail.com
ORCID iD: 0000-0002-3162-6298
SPIN 代码: 8640-9591
MD, Cand. Sci. (Med.)
俄罗斯联邦, Krasnoyarsk; KrasnoyarskOlga Veselova
Federal Siberian Research Clinical Centre; Krasnoyarsk State Medical University; Saint-Petersburg State Pediatric Medical University
Email: veselovaof@mail.ru
ORCID iD: 0000-0002-6126-665X
SPIN 代码: 4340-0455
MD, Cand. Sci. (Med.)
俄罗斯联邦, Krasnoyarsk; Krasnoyarsk; Saint-PetersburgEkaterina Khinovker
Krasnoyarsk State Medical University
Email: khinov@mail.ru
ORCID iD: 0000-0002-8860-9480
SPIN 代码: 7440-1924
俄罗斯联邦, Krasnoyarsk
Viktor Koryachkin
Saint-Petersburg State Pediatric Medical University
Email: vakoryachkin@mail.ru
ORCID iD: 0000-0002-3400-8989
SPIN 代码: 6101-0578
MD, Dr. Sci. (Med.), professor
俄罗斯联邦, Saint-Petersburg参考
- Brennan F, Carr DB, Cousins M. Pain management: a fundamental human right. Anesth Analg. 2007;105(1):205–221. doi: 10.1213/01.ane.0000268145.52345.55
- Mills SEE, Nicolson KP, Smith BH. Chronic pain: a review of its epidemiology and associated factors in population-based studies. Br J Anaesth. 2019;123(2):e273–e283. doi: 10.1016/j.bja.2019.03.023
- Verhaak PFM, Kerssens JJ, Dekker J, et al. Prevalence of chronic benign pain disorder among adults: a review of the literature. Pain. 1998;77(3):231–239. doi: 10.1016/s0304-3959(98)00117-1
- Yakhno NN, Kukushkin ML, Danilov AB, et al. Rezul’taty Rossiiskogo epidemiologicheskogo issledovaniya rasprostranennosti nevropaticheskoi boli, ee prichin i kharakteristik v populyatsii ambulatornykh bol’nykh, obrativshikhsya k vrachu-nevrologu. Bol’. 2008;(3):24–32. (In Russ).
- Thomson SJ, Tavakkolizadeh M, Love-Jones S, et al. Effects of Rate on Analgesia in Kilohertz Frequency Spinal Cord Stimulation: Results of the PROCO Randomized Controlled Trial. Neuromodulation. 2018;21(1):67–76. doi: 10.1111/ner.12746
- Cavalli E, Mammana S, Nicoletti F, et al. The neuropathic pain: An overview of the current treatment and future therapeutic approaches. Int J Immunopathol Pharmacol. 2019;33:2058738419838383. doi: 10.1177/2058738419838383
- Diagnostika i lechenie boli. Van Roenn JH, Peis JA, Preoder MI. Moscow: BINOM; 2012. 496 p. (In Russ).
- Meske DS, Lawal OD, Elder H, et al. Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials. J Pain Res. 2018;11:923–934. doi: 10.2147/JPR.S160255
- Richebe P, Rivat C, Creton C, et al. Nitrous oxide revisited: evidence for potent antihyperalgesic properties. Anesthesiology. 2005;103(4):845–854. doi: 10.1097/00000542-200510000-00024
- Khinovker VV, Khinovker EV. Animal models of chronic pain. In vivo experiments. Regional Anesthesia and Acute Pain Management. 2021;14(3):121–129. doi: 10.17816/1993-6508-2020-14-3-121-129
- Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33(1):87–107. doi: 10.1016/0304-3959(88)90209-6
- Thomson SJ, Tavakkolizadeh M, Love-Jones S, et al. Effects of Rate on Analgesia in Kilohertz Frequency Spinal Cord Stimulation: Results of the PROCO Randomized Controlled Trial. Neuromodulation. 2018;21(1):67–76. doi: 10.1111/ner.12746
- Sapon NA, Chitaeva GE. Neurological pain syndrome experimental design and intensity estimation. Ukrainian Neurosurgical Journal. 2006;(1):111–117. (In Russ).
- Asghar A, Aamir MN, Sheikh FA, Ahmad N, Elsherif MA, Abbas Bukhari SN. Co-Combination of Pregabalin and Withaniacoagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model. Molecules. 2022;27(14):4433. doi: 10.3390/molecules27144433