CENTRAL ACTIVITY ANALGETIC NEFOPAM AS A COMPONENT OF ANALGOSEDATION IN OPHTHALMOSURGERY


Cite item

Full Text

Abstract

Prospective research was made to evaluate the efficiency of nefopam in anasthesiology manual- analgosedation with preserved consciousness- during anticataractal and antiglaucoma operations. The research involved 2 groups of patients: with nefopam analgesia and tramadol analgesia. Data of research includes evaluation of the dynamics of hemodynamic information and oxygenation, rate of intraoperation critical incidents (oculocardiac syndrome, other arrhythmias, hypertension and hypotension). By verbal pain assessment scale we have compared the level of intraoperation analgesia. We get the following results: combination of nefopam and droperidol provides analgosedation which is more hemodynamic stable and has significantly lower intraoperation critical incidents then analgosedation of tramadol. Nefopam has undesirable side effects like temperate increase in heart rate and pain during injection along the vein in combination with ketorolac. Sufficient dose for analgesia at old-aged patients in ophthalmosurgical practice is 10 mg of nefopam.

About the authors

Victoria V. Myasnikova

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation; Kuban State Medical University of the Ministry of Public Health of the Russian Federation

Email: vivlad7@rambler.ru
MD. PhD, DSc, the Head of the Department of Anaesthesiology and Reanimation the Academician S.N. Fyodorov IRTC «Eye Microsurgery», Krasnodar Branch, 350012, Krasnodar, Russian Federation Krasnodar Branch, 350012, Krasnodar, Russian Federation; 350063, Krasnodar, Russian Federation

U. V Bityukov

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation

Krasnodar Branch, 350012, Krasnodar, Russian Federation

S. V Dereza

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation

Krasnodar Branch, 350012, Krasnodar, Russian Federation

I. V Kuznetcov

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation

Krasnodar Branch, 350012, Krasnodar, Russian Federation

O. V Poryadina

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation

Krasnodar Branch, 350012, Krasnodar, Russian Federation

S. S Fedorenko

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation

Krasnodar Branch, 350012, Krasnodar, Russian Federation

I. V Cherkasova

The academician S.N. Fyodorov IRTC «Eye Microsurgery» of the Ministry of Public Health of the Russian Federation

Krasnodar Branch, 350012, Krasnodar, Russian Federation

S. V Chuprin

Kuban State Medical University of the Ministry of Public Health of the Russian Federation

350063, Krasnodar, Russian Federation

References

  1. Тахчиди Х.П., Сахнов С.Н., Мясникова В.В., Галенко-Ярошевский П.А. Анестезия в офтальмологии. Москва: МИА, 2007: 90-1.
  2. Гаджимурадов К.Н., Хагвердиев Ф.Т. Обеспечение безопасности пациентов при витреоретинальных операциях. Вiсник проблем бiологii i медицини. 2015; 3; 2 (123): 17-22.
  3. Хмельницкий И.В., Горбачев В.И., Маньков А.В., Горбачева С.М. Особенности анестезиологического пособия в амбулаторной практике. Вестник интенсивной терапии. 2015; 2: 50-6.
  4. Kristensen S.D., Knuuti J., Saraste A. et al. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management. European Heart Journal. 2014; 35: 2383-2431. doi: 10.1093/eurheartj/ehu282.
  5. Scott I.U., Gayer S., Voo I., et al. Regional anesthesia with monitored anesthesia care for surgical repair of selectedopen globe injuries. Ophthalmic Surg. Lasers Imagining. 2005; 36: 122-8.
  6. Бунатян А.А., Мизиков В.М., ред. Анестезиология: национальное руководство. М.: ГЭОТАР-Медиа, 2011.
  7. Charles S., Fanning G.L. Anesthesia considerations for vitreoretinal surgery.Ed. by Moster M.R., Azuara-Blanco A. Ocular Anesthesia.Оphthalmol. Clin. N. Am. 2006; 19 (2): 239-43.
  8. Kristin N., Schonfeld C.L., Bechmann M. et al. Vitreoretinal surgery: pre-emptive analgesia. British Journal of Ophthalmology. 2001 (85): 1328-31.
  9. Moster M.R., Azuara-Blanco A. Ocular Anesthesia.Оphthalmol. Clin. N. Am. 2006; 19 (2): 151-322.
  10. Бараш П. Д., Куллен Б.Ф., Стэлтинг Р.К. Клиническая анестезиология. Пер. с англ. М.: Медицинская литература; 2010.
  11. Берлинский В.В., Максимов В.Ю., Чумаков Л.А., Козлов С.А. Первый опыт применения дексмедетомидина в витреоретинальной хирургии. В кн.: Сборник тезисов XV съездa Федерации анестезиологов и реаниматологов 17-20 сентября 2016, Москва, 2016; 52-4.
  12. Овечкин А.М., Политов М.Е. Послеоперационное обезболивание с точки зрения доказательной медицины. Вестник интенсивной терапии. 2016; 2: 51-60.
  13. Rosland J.H., Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. J. Pharm. Pharmacol. 1990; 4 2 (6): 437-8. doi: 10.1111/j.2042-7158.1990.tb06587.x
  14. Novelli A., Díaz-Trelles R., Groppetti A., et al. Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels. Amino Acids. 2005; 28 (2): 183-91.
  15. Durrieu G., Oliver P., Bagheri H. et al. Overview of adverse reaction to nefopam: an analysis of the French Pharmacovigilance database. Fundamental & Pharmacology. 2007; 21: 555-8.

Copyright (c) 2017 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies