EFFECT OF DEXAMETHASONE ON QUALITY OF THE ANALGESIC EFFECT OF PERIPHERAL BLOCKADES


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Abstract

Objective. The aim of the work was to assessment the analgesic effect of dexamethasone at peripheral nerve blockades. Material and methods. The study included 166 patients, including 45 children aged from 3 to 16 years of age, randomized into 3 groups. For blockages in peripheral nerves of the 1st group received 0.5% solution ropivacine, in the 2 nd group - 0.5% solution ropivacine and dexamethasone intravenous, 3 rd group - 0.5% solution ropivacine and dexamethasone. Results. Duration period painless adults was 12.8±7.1 h, 22.8±4.8 h and 24,1±6,8 h, children 8.3±1.5 h, 10.4±1.7 h and 20±5 h, respectively. It is shown that the use of dexamethasone protects the patient from nociceptive afferentation in the postoperative period. Possible mechanisms of the analgesic effect of dexamethasone was discussed. Conclusion. Further research is needed to study the mechanism of analgesic action of dexamethasone.

About the authors

Dmitriy V. Zabolotskii

Saint-Petersburg State Pediatric Medical University; G.I. Turner Research Pediatric Orthopedic Institute

Email: zdv4330303@gmail.com
MD, PhD, DSc, Professor of the Department of anesthesiology and resuscitation, Saint-Petersburg State Pediatric Medical University, 194100, Saint-Petersburg, Russian Federation 194100, Saint-Petersburg, Russian Federation; 196603, Saint-Petersburg, Russian Federation

V. A Koriachkin

R.R Vreden Russian Scientific and Research Institute for Traumatology and Orthopedics

195427, Saint-Petersburg, Russian Federation

A. N Savenkov

Saint-Petersburg State Pediatric Medical University; G.I. Turner Research Pediatric Orthopedic Institute

194100, Saint-Petersburg, Russian Federation; 196603, Saint-Petersburg, Russian Federation

E. Y Fel’ker

Saint-Petersburg State Pediatric Medical University

194100, Saint-Petersburg, Russian Federation

A. V Lavrenchuk

R.R Vreden Russian Scientific and Research Institute for Traumatology and Orthopedics

195427, Saint-Petersburg, Russian Federation

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