Systemic toxicity of local anesthetics in regional anesthesia


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Abstract

The article presents description of clinical case of lipid emulsion rescue during severe toxic reaction occurred in reply to accidental intravenous injection of local anesthetic solution. The article includes comprehensive data about epidemiology, clinical course and treatment of systemic toxicity of local anesthetics. It considers up-to-date understanding of mechanisms of antitoxic effect of lipid emulsion. The protocol of lipid emulsion rescue during systemic toxicity of local anesthetics is presented in the paper.

About the authors

Victor A. Koryachkin

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

Email: vakoryachkin@mail.ru
195427, Saint-Petersburg

E. V Geras’kov

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

195427, Saint-Petersburg

V. S Kazarin

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

195427, Saint-Petersburg

M. A Lis’kov

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

195427, Saint-Petersburg

M. Mokhanna

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

195427, Saint-Petersburg

M. P Mal’tse

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

195427, Saint-Petersburg

G. M Malevich

FSBI “P.P. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics” MHC of RF

195427, Saint-Petersburg

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