Spectral-Fluorescent Properties of Supramolecular Systems Based on Chlorin e6

Аннотация

The spectral-fluorescent properties of various supramolecular systems based on chlorin e₆ (Ce₆) are determined to facilitate the development of new medicines for photodynamic therapy and diagnostics. The effect of various excipients, such as poly-N-vinylpyrrolidone (PVP), polyethylene glycol (PEG), bovine serum albumin (BSA), chitosan, Triton X-100 (TX-100), sodium hexametaphosphate (SHMP), and poly(dimethyldiallylammonium chloride) chloride (PDDAC), on the optical absorption and fluorescence of Ce₆ is demonstrated. In the Ce₆−PVP, Ce₆−PEG, Ce₆−BSA, Ce₆−TX-100, Ce₆−SHMP, and Ce₆−PDDAC systems, Ce₆ molecules are disaggregated and complexes thereof with excipients are formed. The quantum yield of Ce₆ fluorescence in supramolecular systems is close to that of the free-form photosensitizer, in the absence of excipients. The results suggest that supramolecular complexes of Ce₆ are promising for the development of medicines with controllable photodynamic activity.