Отправить статью по E-mail Micronization of levofloxacin by supercritical antisolvent precipitation
- Авторы: Kudryashova E.V.1, Popov V.K.2, Krotova L.I.2, Dunaev A.G.2, Antonov E.N.2, Parenago O.O.1,3, Ustinovich K.B.1,3, Pokrovskiy O.I.3, Vorobei A.M.1,3, Klyachko N.L.1, Filatova L.Y.1, Sukhoverkov K.V.1, Deygen I.M.1, Egorov A.M.1,4
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Учреждения:
- Department of Chemistry
- Institute of Laser and Information Technologies
- Kurnakov Institute of General and Inorganic Chemistry
- Russian Medical Academy of Postgraduate Education
- Выпуск: Том 10, № 8 (2016)
- Страницы: 1201-1210
- Раздел: Article
- URL: https://journals.rcsi.science/1990-7931/article/view/198730
- DOI: https://doi.org/10.1134/S1990793116080054
- ID: 198730
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Аннотация
The process of micronization of levofloxacin (LF, an antibacterial agent of the fluoroquinolone group) by the supercritical antisolvent precipitation technique (SAS) was investigated. It was shown that LF particles of different sizes (from 1 to 10 μm) and of various morphologies (from thin plates to elongated parallelepipeds) can be produced depending on the type of solvent used for conducting micronization. Investigation of the micronized LF preparations using the methods of IR-Fourier spectroscopy, Raman scattering, and circular dichroism showed that the LF micronization caused neither changes in its chemical structure nor racemization. Micronization of LF significantly affects the rate of its dissolution in model systems exhibiting effects dependent on the type of the solvent used for micronization. For example, the highest rate of dissolution at pH 4 was observed for LF preparations micronized with the help of chlorohydrocarbons. It was shown that the rate of dissolution of all micronized LF preparations was higher by 15–30% in comparison with the initial LF, which likely was related to the changes in the degree of crystallinity/amorphousness, as well as of morphologies of microparticles formed in the SAS process.
Об авторах
E. Kudryashova
Department of Chemistry
Автор, ответственный за переписку.
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow
V. Popov
Institute of Laser and Information Technologies
Email: Helena_Koudriachova@hotmail.com
Россия, Troitsk, Moscow
L. Krotova
Institute of Laser and Information Technologies
Email: Helena_Koudriachova@hotmail.com
Россия, Troitsk, Moscow
A. Dunaev
Institute of Laser and Information Technologies
Email: Helena_Koudriachova@hotmail.com
Россия, Troitsk, Moscow
E. Antonov
Institute of Laser and Information Technologies
Email: Helena_Koudriachova@hotmail.com
Россия, Troitsk, Moscow
O. Parenago
Department of Chemistry; Kurnakov Institute of General and Inorganic Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow; Moscow
K. Ustinovich
Department of Chemistry; Kurnakov Institute of General and Inorganic Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow; Moscow
O. Pokrovskiy
Kurnakov Institute of General and Inorganic Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow
A. Vorobei
Department of Chemistry; Kurnakov Institute of General and Inorganic Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow; Moscow
N. Klyachko
Department of Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow
L. Filatova
Department of Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow
K. Sukhoverkov
Department of Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow
I. Deygen
Department of Chemistry
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow
A. Egorov
Department of Chemistry; Russian Medical Academy of Postgraduate Education
Email: Helena_Koudriachova@hotmail.com
Россия, Moscow; Moscow
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