EPR Diagnostics of D,L-Polylactide Porous Matrices Formed in Supercritical CO2
- Авторы: Chumakova N.1, Golubeva E.1, Ivanova T.1, Vorobieva N.2, Timashev P.2,3, Bagratashvili V.2
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Учреждения:
- Moscow State University
- Institute of Photonic Technologies, Crystallography and Photonics Research Center
- Institute for Regenerative Medicine
- Выпуск: Том 12, № 8 (2018)
- Страницы: 1255-1260
- Раздел: Article
- URL: https://journals.rcsi.science/1990-7931/article/view/201633
- DOI: https://doi.org/10.1134/S1990793118080031
- ID: 201633
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Аннотация
The regularities of formation of D,L-polylactide porous matrices in supercritical CO2 environment with simultaneous impregnation with paramagnetic biologically active 4-hydroxy-2,2,6,6-tetramethylpiperidine- 1-oxyl (TEMPOL) was studied using spin probe electron paramagnetic resonance (EPR) and optical microscopy. The dependence of the average and local concentration of a dopant on impregnation conditions was assessed. The resulting matrices meet important requirements for porous materials for tissue engineering. Considering that impregnation of a polymer with a paramagnetic compound makes it possible to study the uniform distribution of a dopant in a sample at macroscopic and microscopic levels and to study a structure of a polymer matrix, EPR spectroscopy is a promising method for studying porous polymeric materials formed under supercritical conditions.
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Об авторах
N. Chumakova
Moscow State University
Автор, ответственный за переписку.
Email: harmonic2011@yandex.ru
Россия, Moscow
E. Golubeva
Moscow State University
Email: harmonic2011@yandex.ru
Россия, Moscow
T. Ivanova
Moscow State University
Email: harmonic2011@yandex.ru
Россия, Moscow
N. Vorobieva
Institute of Photonic Technologies, Crystallography and Photonics Research Center
Email: harmonic2011@yandex.ru
Россия, Moscow
P. Timashev
Institute of Photonic Technologies, Crystallography and Photonics Research Center; Institute for Regenerative Medicine
Email: harmonic2011@yandex.ru
Россия, Moscow; Moscow
V. Bagratashvili
Institute of Photonic Technologies, Crystallography and Photonics Research Center
Email: harmonic2011@yandex.ru
Россия, Moscow