Antiradical and Anti-Stress Properties of N-Acetylcysteinate 2-Ethyl-6-Methyl-3-Hydroxypyridine

Abstract

The antiradical features and biological activity of N-acetylcysteinate 2-ethyl-6-methyl-3-hydroxypyridine have been studied. The high antiradical activity of this drug has been shown by the chemiluminescence method. The drug, in concentrations of 10^–6–10^–11 and 10^–13 M, has prevented the activation of lipid peroxidation (LPO) in mitochondrial membranes of pea seedlings (Pisum sativum L., cv. Flora and cv. Alpha). Preventing the activation of LPO, N-acetylcysteinate 2-ethyl-6-methyl-3-hydroxypyridine has contributed to the preservation of the functional state of mitochondria, which affected the physiological parameters: the drug has prevented a decrease in the growth rates of pea seedlings under stress conditions (water deficiency). It is suggested that maintaining the high functional activity of mitochondria determines the protective activity of this compound.