Enzymatic Decomposition of Chitosan-Based Film Materials Modified by Antibiotics of the Cephalosporin Series


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Abstract

The enzymatic decomposition of film materials based on chitosan with inclusions of cephalosporin antibiotics on a substrate impregnated with Ringer–Locke’s solution was studied. The introduction of antibiotics led to a decrease in the rate of the enzymatic decomposition of chitosan, as in the case of chitosan lysis in the presence of aminoglycoside antibiotics. A possible reason for the decrease in the rate of the enzymatic decomposition of chitosan is suppression of polyelectrolyte swelling in the presence of low-molecular electrolytes including medicinal agents. The introduction of drugs in the chitosan-based film is a potential method for selectively decreasing the rate of enzymatic hydrolysis of chitosan for increasing the service life of the film material on a wound surface.

About the authors

V. V. Chernova

Bashkir State University

Email: onlyalena@mail.ru
Russian Federation, Ufa, 450076

A. S. Shurshina

Bashkir State University

Email: onlyalena@mail.ru
Russian Federation, Ufa, 450076

E. I. Kulish

Bashkir State University

Author for correspondence.
Email: onlyalena@mail.ru
Russian Federation, Ufa, 450076

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