Enzymatic Decomposition of Chitosan-Based Film Materials Modified by Antibiotics of the Cephalosporin Series
- Authors: Chernova V.V.1, Shurshina A.S.1, Kulish E.I.1
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Affiliations:
- Bashkir State University
- Issue: Vol 12, No 3 (2018)
- Pages: 495-502
- Section: Chemical Physics of Biological Processes
- URL: https://journals.rcsi.science/1990-7931/article/view/200576
- DOI: https://doi.org/10.1134/S1990793118030235
- ID: 200576
Cite item
Abstract
The enzymatic decomposition of film materials based on chitosan with inclusions of cephalosporin antibiotics on a substrate impregnated with Ringer–Locke’s solution was studied. The introduction of antibiotics led to a decrease in the rate of the enzymatic decomposition of chitosan, as in the case of chitosan lysis in the presence of aminoglycoside antibiotics. A possible reason for the decrease in the rate of the enzymatic decomposition of chitosan is suppression of polyelectrolyte swelling in the presence of low-molecular electrolytes including medicinal agents. The introduction of drugs in the chitosan-based film is a potential method for selectively decreasing the rate of enzymatic hydrolysis of chitosan for increasing the service life of the film material on a wound surface.
About the authors
V. V. Chernova
Bashkir State University
Email: onlyalena@mail.ru
Russian Federation, Ufa, 450076
A. S. Shurshina
Bashkir State University
Email: onlyalena@mail.ru
Russian Federation, Ufa, 450076
E. I. Kulish
Bashkir State University
Author for correspondence.
Email: onlyalena@mail.ru
Russian Federation, Ufa, 450076
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