Email this article Fabrication of the Components for a Sustained-Release Injectable Dosage Form of Acetylsalicylic Acid Using Supercritical Carbon Dioxide
- Authors: Antonov E.N.1, Bogorodskii S.E.1, Krotova L.I.1, Popov V.K.1, Belov V.Y.2, Kursakov S.V.2, Sevastyanov V.I.2,3
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Affiliations:
- Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics
- Institute of Medical and Biological Research and Technologies
- Shumakov Federal Research Center of Transplantology and Artificial Organs
- Issue: Vol 11, No 7 (2017)
- Pages: 1056-1060
- Section: Article
- URL: https://journals.rcsi.science/1990-7931/article/view/199957
- DOI: https://doi.org/10.1134/S1990793117070028
- ID: 199957
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Abstract
Fabrication of fine-grained (10–100 μm) bioresorbable powders of aliphatic polyesters containing therapeutically significant (up to 10 wt %) concentrations of acetylsalicylic acid using supercritical CO2 is studied. The process for fabricating the components of sustained-release injectable dosage forms of acetylsalicylic acid is elaborated. The kinetics of release of acetylsalicylic acid from polylactide microparticles into the normal saline solution in vitro is studied by high-performance liquid chromatography.
About the authors
E. N. Antonov
Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics
Email: popov@laser.ru
Russian Federation, Troitsk, Moscow
S. E. Bogorodskii
Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics
Email: popov@laser.ru
Russian Federation, Troitsk, Moscow
L. I. Krotova
Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics
Email: popov@laser.ru
Russian Federation, Troitsk, Moscow
V. K. Popov
Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics
Author for correspondence.
Email: popov@laser.ru
Russian Federation, Troitsk, Moscow
V. Yu. Belov
Institute of Medical and Biological Research and Technologies
Email: popov@laser.ru
Russian Federation, Moscow
S. V. Kursakov
Institute of Medical and Biological Research and Technologies
Email: popov@laser.ru
Russian Federation, Moscow
V. I. Sevastyanov
Institute of Medical and Biological Research and Technologies; Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: popov@laser.ru
Russian Federation, Moscow; Moscow
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