The combined action of binase and bleomycin on human lung adenocarcinoma cells
- Autores: Zelenikhin P.V.1, Makeeva A.V.1, Nguen T.N.2, Siraj Y.A.1,2, Ilinskaya O.N.1
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Afiliações:
- Institute of Fundamental Medicine and Biology
- College of Medicine and Health Sciences
- Edição: Volume 10, Nº 1 (2016)
- Páginas: 87-90
- Seção: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/197191
- DOI: https://doi.org/10.1134/S1990750816010121
- ID: 197191
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Resumo
Some microbial ribonucleases (RNases) demonstrate selective cytotoxic effect against a wide range of tumor cells. In this context combined use of cytotoxic RNases in complex therapy with other chemotherapeutic agents appears to be especially promising. In this study we have investigated the apoptosisinduced effect of Bacillus pumilus RNase (binase) in combination with known antitumor antibiotic bleomycin on human lung adenocarcinoma A549 cells. The combined effect of high concentrations of these agents did not have any mutual increase in their apoptosisinduced action, while a combination of nonapoptotic concentrations resulted in the increase of proportion of apoptotic cells up to 22% as compared with individual effect of bleomycin (6%) and binase (12%) used separately. These results indicate that binase and bleomycin are effective in combination of their low concentrations and ineffective in combination of their high concentrations.
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Sobre autores
P. Zelenikhin
Institute of Fundamental Medicine and Biology
Autor responsável pela correspondência
Email: pasha_mic@mail.ru
Rússia, ul. Kremlyovskaya 18, Kazan, 420008
A. Makeeva
Institute of Fundamental Medicine and Biology
Email: pasha_mic@mail.ru
Rússia, ul. Kremlyovskaya 18, Kazan, 420008
T. Nguen
College of Medicine and Health Sciences
Email: pasha_mic@mail.ru
Etiópia, Bahir Dar, 79
Y. Siraj
Institute of Fundamental Medicine and Biology; College of Medicine and Health Sciences
Email: pasha_mic@mail.ru
Rússia, ul. Kremlyovskaya 18, Kazan, 420008; Bahir Dar, 79
O. Ilinskaya
Institute of Fundamental Medicine and Biology
Email: pasha_mic@mail.ru
Rússia, ul. Kremlyovskaya 18, Kazan, 420008
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