The Role of Mitochondrial DNA ORIB Polymorphism in Metabolic Syndrome
- 作者: Skuratovskaia D.A.1, Sofronova J.K.1, Zatolokin P.A.2, Vasilenko M.A.1, Litvinova L.S.1, Mazunin I.O.1
-
隶属关系:
- Immanuel Kant Baltic Federal University
- Regional Clinical Hospital of the Kaliningrad Region
- 期: 卷 12, 编号 1 (2018)
- 页面: 59-65
- 栏目: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/198044
- DOI: https://doi.org/10.1134/S1990750818010109
- ID: 198044
如何引用文章
详细
The development of the metabolic syndrome (MS) involves many genes. Certain evidence exists in the literature on the association of polymorphism in the mitochondrial DNA (mtDNA) oriB site, also known as the polycytosine pathway, with the development of insulin resistance, type 2 diabetes mellitus (T2DM) and other metabolic disorders in various ethnic populations. It is suggested that certain polymorphisms at this site are associated with mtDNA copy number in the cell. In this study, using capillary sequencing, we have identified various allelic variants of the mtDNA oriB site in patients with MS (n = 106) and conditionally healthy donors (n = 71). The mtDNA copy number in blood leukocytes was determined by the droplet digital polymerase chain reaction (ddPCR). It has been shown that the variant of the continuous polycytosine tract is significantly more frequent in MS patients with T2DM (p < 0.01). In general, the mtDNA copy number of blood leukocytes was lower in MS patients than in controls. We did not find any correlations between the oriB site variability and the mtDNA copy number.
作者简介
D. Skuratovskaia
Immanuel Kant Baltic Federal University
Email: IMazunin@kantiana.ru
俄罗斯联邦, ul. Alexandra Nevskoro 14, Kaliningrad, 236038
J. Sofronova
Immanuel Kant Baltic Federal University
Email: IMazunin@kantiana.ru
俄罗斯联邦, ul. Alexandra Nevskoro 14, Kaliningrad, 236038
P. Zatolokin
Regional Clinical Hospital of the Kaliningrad Region
Email: IMazunin@kantiana.ru
俄罗斯联邦, ul. Klinicheskaya 74, Kaliningrad, 236019
M. Vasilenko
Immanuel Kant Baltic Federal University
Email: IMazunin@kantiana.ru
俄罗斯联邦, ul. Alexandra Nevskoro 14, Kaliningrad, 236038
L. Litvinova
Immanuel Kant Baltic Federal University
Email: IMazunin@kantiana.ru
俄罗斯联邦, ul. Alexandra Nevskoro 14, Kaliningrad, 236038
I. Mazunin
Immanuel Kant Baltic Federal University
编辑信件的主要联系方式.
Email: IMazunin@kantiana.ru
俄罗斯联邦, ul. Alexandra Nevskoro 14, Kaliningrad, 236038
补充文件
