Nitrobenzofuroxane derivatives as dual action HIV-1 inhibitors


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Human immunodeficiency virus type 1 (HIV-1) causes one of the most dangerous diseases, HIV infection and AIDS. The search for new inhibitors of the virus still remains an urgent task. One of approaches to suppress the HIV infection is the use of dual action HIV-1 inhibitors, i.e. inhibitors targeting two stages of the viral life cycle. The catalytic domain of HIV-1 integrase shares similar structural organization with the ribonuclease (RNase H) domain of HIV-1 reverse transcriptase, and therefore an approach aimed at creation of dual action inhibitors which would simultaneously inhibit HIV-1 integrase and RNase H seems to be very promising. In this work we have synthesized a series of 6-nitrobenzofuroxane derivatives and studied their inhibitory activity towards two HIV-1 enzymes, integrase and RNase H.

作者简介

S. Korolev

Department of Chemistry and Belozersky Institute of Physico-Chemical Biology

编辑信件的主要联系方式.
Email: spkorolev@mail.ru
俄罗斯联邦, Moscow, 119991

M. Pustovarova

Department of Chemistry and Belozersky Institute of Physico-Chemical Biology

Email: spkorolev@mail.ru
俄罗斯联邦, Moscow, 119991

A. Starosotnikov

Zelinsky Institute of Organic Chemistry

Email: spkorolev@mail.ru
俄罗斯联邦, Moscow

M. Bastrakov

Zelinsky Institute of Organic Chemistry

Email: spkorolev@mail.ru
俄罗斯联邦, Moscow

Yu. Agapkina

Department of Chemistry and Belozersky Institute of Physico-Chemical Biology

Email: spkorolev@mail.ru
俄罗斯联邦, Moscow, 119991

S. Shevelev

Zelinsky Institute of Organic Chemistry

Email: spkorolev@mail.ru
俄罗斯联邦, Moscow

M. Gottikh

Department of Chemistry and Belozersky Institute of Physico-Chemical Biology

Email: spkorolev@mail.ru
俄罗斯联邦, Moscow, 119991

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