Peptide phage display in biotechnology and biomedicine


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

To date peptide phage display is one of the most common combinatorial methods used for identifying specific peptide ligands. Phage display peptide libraries containing billions different clones successfully used for selection of ligands with high affinity and selectivity toward wide range of targets including individual proteins, bacteria, viruses, spores, different kind of cancer cells and variety of nonorganic targets (metals, alloys, semiconductors, etc.). Success of using filamentous phage in phage display technologies relays on the robustness of phage particles and a possibility to genetically modify its DNA to construct new phage variants with novel properties. In this review we are discussing characteristics of the most known non-commercial peptide phage display libraries of different formats (landscape libraries in particular) and their successful applications in several fields of biotechnology and biomedicine: discovery of peptides with diagnostic values against different pathogens, discovery and using of peptides recognizing cancer cells, trends in using of phage display technologies in human interactome studies, application of phage display technologies in construction of novel nanomaterials.

作者简介

G. Kuzmicheva

Research Center of Virology and Biotechnology Vector; XBiotech USA

编辑信件的主要联系方式.
Email: kouzmitcheva@yahoo.com
俄罗斯联邦, Koltsovo, Novosibirsk region, 630558; East Riverside Drive 8201, bld. 4, Austin, TX, 78744

V. Belyavskaya

Research Center of Virology and Biotechnology Vector

Email: kouzmitcheva@yahoo.com
俄罗斯联邦, Koltsovo, Novosibirsk region, 630558

补充文件

附件文件
动作
1. JATS XML

版权所有 © Pleiades Publishing, Ltd., 2017