Peptide phage display in biotechnology and biomedicine
- 作者: Kuzmicheva G.A.1,2, Belyavskaya V.A.1
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隶属关系:
- Research Center of Virology and Biotechnology Vector
- XBiotech USA
- 期: 卷 11, 编号 1 (2017)
- 页面: 1-15
- 栏目: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/197589
- DOI: https://doi.org/10.1134/S1990750817010061
- ID: 197589
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详细
To date peptide phage display is one of the most common combinatorial methods used for identifying specific peptide ligands. Phage display peptide libraries containing billions different clones successfully used for selection of ligands with high affinity and selectivity toward wide range of targets including individual proteins, bacteria, viruses, spores, different kind of cancer cells and variety of nonorganic targets (metals, alloys, semiconductors, etc.). Success of using filamentous phage in phage display technologies relays on the robustness of phage particles and a possibility to genetically modify its DNA to construct new phage variants with novel properties. In this review we are discussing characteristics of the most known non-commercial peptide phage display libraries of different formats (landscape libraries in particular) and their successful applications in several fields of biotechnology and biomedicine: discovery of peptides with diagnostic values against different pathogens, discovery and using of peptides recognizing cancer cells, trends in using of phage display technologies in human interactome studies, application of phage display technologies in construction of novel nanomaterials.
作者简介
G. Kuzmicheva
Research Center of Virology and Biotechnology Vector; XBiotech USA
编辑信件的主要联系方式.
Email: kouzmitcheva@yahoo.com
俄罗斯联邦, Koltsovo, Novosibirsk region, 630558; East Riverside Drive 8201, bld. 4, Austin, TX, 78744
V. Belyavskaya
Research Center of Virology and Biotechnology Vector
Email: kouzmitcheva@yahoo.com
俄罗斯联邦, Koltsovo, Novosibirsk region, 630558
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