Activity of redox-regulatory systems in the tumor and surrounding tissues in various histological types of tumors

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According to modern concepts, a malignant tumor is a complex dynamic system possessing numerous links with both the immediate environment and remote non-malignant tissues and organs. Changes in their redox balance can result in disruption of the normal tissue control. The aim of our study was to compare activity of enzymes influencing the redox state in the tumor tissue, peritumoral area, and nonmalignant tissues (taken by resection line) at various histological tumor variants. We found similar close level of reduced glutathione in the tissues of gastric adenocarcinoma and vulvar squamous cell carcinoma; however, dynamics of this parameter in the tumor surrounding tissues was different. In contrast to gastric adenocarcinoma, vulvar squamous cell carcinoma was characterized by a significant increase in glutathione content in the tumor tissue and increased activity of all investigated enzymes of the glutathione system in the tumor tissue and its peritumoral area as compared with the surrounding non-malignant tissue. These results underlie existence of clear differences in the functioning of the redox regulatory systems in the tumor and surrounding tissues of various histological origin and localization; these differences may be possibly attributed to different mechanisms involved in maintenance of the redox balance in the originally non-malignant tissues.

作者简介

E. Surikova

Rostov Research Institute of Oncology

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Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

I. Goroshinskaja

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

G. Nerodo

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

E. Frantsiyants

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

M. Malejko

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

E. Shalashnaja

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

P. Kachesova

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

L. Nemashkalova

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

A. Leonova

Rostov Research Institute of Oncology

Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037

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