Activity of redox-regulatory systems in the tumor and surrounding tissues in various histological types of tumors
- 作者: Surikova E.I.1, Goroshinskaja I.A.1, Nerodo G.A.1, Frantsiyants E.M.1, Malejko M.L.1, Shalashnaja E.V.1, Kachesova P.S.1, Nemashkalova L.A.1, Leonova A.V.1
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隶属关系:
- Rostov Research Institute of Oncology
- 期: 卷 10, 编号 4 (2016)
- 页面: 335-340
- 栏目: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/197547
- DOI: https://doi.org/10.1134/S1990750816040089
- ID: 197547
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详细
According to modern concepts, a malignant tumor is a complex dynamic system possessing numerous links with both the immediate environment and remote non-malignant tissues and organs. Changes in their redox balance can result in disruption of the normal tissue control. The aim of our study was to compare activity of enzymes influencing the redox state in the tumor tissue, peritumoral area, and nonmalignant tissues (taken by resection line) at various histological tumor variants. We found similar close level of reduced glutathione in the tissues of gastric adenocarcinoma and vulvar squamous cell carcinoma; however, dynamics of this parameter in the tumor surrounding tissues was different. In contrast to gastric adenocarcinoma, vulvar squamous cell carcinoma was characterized by a significant increase in glutathione content in the tumor tissue and increased activity of all investigated enzymes of the glutathione system in the tumor tissue and its peritumoral area as compared with the surrounding non-malignant tissue. These results underlie existence of clear differences in the functioning of the redox regulatory systems in the tumor and surrounding tissues of various histological origin and localization; these differences may be possibly attributed to different mechanisms involved in maintenance of the redox balance in the originally non-malignant tissues.
作者简介
E. Surikova
Rostov Research Institute of Oncology
编辑信件的主要联系方式.
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
I. Goroshinskaja
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
G. Nerodo
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
E. Frantsiyants
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
M. Malejko
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
E. Shalashnaja
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
P. Kachesova
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
L. Nemashkalova
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
A. Leonova
Rostov Research Institute of Oncology
Email: rnioi.biochem@gmail.com
俄罗斯联邦, 14-Line 63, Rostov-on-Don, 344037
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