Urea formation by postoperative liver


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Abstract

The effect of liver left lobe resection (LR, 15–20% of the organ weight) on hepatic urea formation was investigated in 84 albino rats. The objects used for analysis of urea content included: operated left lobe (LLL), non-operated middle (MLL) lobe of the liver, blood (aorta, v. hepatica, v. porta), and choledochal bile. Arginase activity was examined in liver homogenate. On the day 3 and day 7 after resection reduced arginase activity was detected. LR caused a decrease in urea content in v. hepatica, but increased urea content in the arterial blood and v. porta. The increase in bile urea on day 7 was then changed for its decrease observed on day 14 of the postoperative period. The urea content in the liver on day 3 after LR was below the norm, while on days 7 and 14 it became normal. Results of this study suggest impaired urea formation by hepatocytes of the operated liver and activation of extrahepatic mechanisms of urea formation from arginine.

About the authors

P. N. Savilov

Tambov Regional Hospital; Burdenko Voronezh State Medical University

Author for correspondence.
Email: p_savilov@rambler.ru
Russian Federation, ul. Polevaya 4, Pokrovo-Prigorodnoe, Tambov region; ul. Studencheskaya 10, Voronezh, 394000

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