Oxidative stress in adipose tissue as a primary link in pathogenesis of insulin resistance

Abstract

Obesity is a leading risk factor of diabetes mellitus type 2 (DM2), impairments of lipid metabolism and cardiovascular diseases. Dysfunctions of the accumulating weight of the visceral fat are primarily linked to pathogenesis of systemic insulin resistance. The review considers modern viewpoints on biochemical mechanisms underlying formation of oxidative stress in adipocytes at obesity, as one of key elements responsible for impairments of their metabolism triggering formation of systemic insulin resistance.