Primary screening of candidate RNA biomarkers for diagnostics of prostate cancer


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Abstract

Applicability of prostate cancer candidate RNA biomarkers screening in plasma and urine obtained by minimally invasive or noninvasive methods has been demonstrated. In patients with benign prostatic hyperplasia (BPH) significant amounts of RNAs known in the literature as biomarkers associated with prostate cancer have been detected in plasma and urine samples. Detectable amounts of the markers depended on the methods used for transcriptome profiling. Detection of known RNA biomarkers associated with prostate cancer in urine and plasma samples by the RNA-seq method shows its applicability for the search of new RNA biomarkers for minimally invasive diagnostics. However, the fact of the presence of known prostate cancer RNA biomarkers in samples from BPH patients suggests their insufficient specificity and indicates a clear need for further research in this field.

About the authors

A. S. Nikitina

Federal Research and Clinical Center of Physical-Chemical Medicine; Moscow Institute of Physics and Technology

Author for correspondence.
Email: quokka.smiles@gmail.com
Russian Federation, ul. Malaya Pirogovskaya 1a, Moscow, 119435; Dolgoprudnyi

V. V. Babenko

Federal Research and Clinical Center of Physical-Chemical Medicine

Email: quokka.smiles@gmail.com
Russian Federation, ul. Malaya Pirogovskaya 1a, Moscow, 119435

K. A. Babalyan

Moscow Institute of Physics and Technology

Email: quokka.smiles@gmail.com
Russian Federation, Dolgoprudnyi

A. O. Vasiliev

Department of Urology

Email: quokka.smiles@gmail.com
Russian Federation, Moscow

A. V. Govorov

Department of Urology

Email: quokka.smiles@gmail.com
Russian Federation, Moscow

E. A. Prilepskaya

Department of Urology

Email: quokka.smiles@gmail.com
Russian Federation, Moscow

S. A. Danilenko

Federal Research and Clinical Center of Physical-Chemical Medicine

Email: quokka.smiles@gmail.com
Russian Federation, ul. Malaya Pirogovskaya 1a, Moscow, 119435

O. V. Selezneva

Federal Research and Clinical Center of Physical-Chemical Medicine

Email: quokka.smiles@gmail.com
Russian Federation, ul. Malaya Pirogovskaya 1a, Moscow, 119435

E. I. Sharova

Federal Research and Clinical Center of Physical-Chemical Medicine

Email: quokka.smiles@gmail.com
Russian Federation, ul. Malaya Pirogovskaya 1a, Moscow, 119435

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