Distribution of translation initiation factor eIF3 in neutrophils in Alzheimer disease

Abstract

The distribution of initiation factor eIF3 in the cytoplasm of peripheral blood neutrophils in Alzheimer disease (AD) was investigated. Using a specially developed image analysis protocol, we found a significant increase in the heterogeneity of the eIF3 distribution in AD neutrophils as compared with control cells. We also obtained an evidence that the increase in the eIF3 heterogeneity in AD neutrophils is associated with the formation of stress granules–non-membrane structures that emerge in the cytoplasm of eukaryotic cells in response to the environmental stress.