Effect of Noradrenaline on the Kinetics of Evoked Acetylcholine Secretion in Mouse Neuromuscular Junction
- Авторлар: Tsentsevitsky A.1, Kovyazina I.1, Bukharaeva E.1, Nikolsky E.2,3
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Мекемелер:
- Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of the Russian Academy of Sciences
- Kazan Medical University
- Kazan Federal University
- Шығарылым: Том 12, № 4 (2018)
- Беттер: 327-332
- Бөлім: Articles
- URL: https://journals.rcsi.science/1990-7478/article/view/213324
- DOI: https://doi.org/10.1134/S1990747818070012
- ID: 213324
Дәйексөз келтіру
Аннотация
In contrast to frog neuromuscular synapses, where noradrenaline (norepinephrine) and its analogues caused synchronization of the acetylcholine release process, in mouse diaphragm endplates noradrenaline increased the degree of asynchrony of neurosecretion. The effect of noradrenaline on release timing persisted at different levels of external calcium ions (0.25–2.0 mM) and was abolished in presence of both α- and β‑adrenoblockers phentolamine and propranolol. The computer reconstruction of multiquantal endplate currents accounting for experimentally observed modification of release kinetics under noradrenaline showed that the rise time of postsynaptic response changes to a greater extent than the amplitude and falling phase of the multiquantal responses. We conclude that there exists a principal difference in the action of noradrenaline in the cholinergic neuromuscular synapses of warm-blooded and cold-blooded animals that can be accounted for by the differences in the type of adrenoreceptors involved in the modulation of synaptic transmission and/or in the involvement of distinct intracellular pathways triggered by receptor activation.
Негізгі сөздер
Авторлар туралы
A. Tsentsevitsky
Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of the Russian Academy of Sciences
Email: irina.kovyazina@list.ru
Ресей, Kazan, P.O. Box 30420111
I. Kovyazina
Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: irina.kovyazina@list.ru
Ресей, Kazan, P.O. Box 30420111
E. Bukharaeva
Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of the Russian Academy of Sciences
Email: irina.kovyazina@list.ru
Ресей, Kazan, P.O. Box 30420111
E. Nikolsky
Kazan Medical University; Kazan Federal University
Email: irina.kovyazina@list.ru
Ресей, Kazan, 420012; Kazan, 420008