Effects of manganese on potassium outflow from erythrocytes and on respiration of rat liver mitochondria


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Abstract

In this work, effects of manganese on respiration of rat liver mitochondria and the rate of K+ outflow from rat erythrocytes are studied in a broad range of concentrations. It is shown that manganese ions at low concentrations (1 × 10–7–3 × 10–5 М) inhibit K+ outflow from rat erythrocytes; this can be used to prevent their lysis. At high concentrations (1 × 10–4–1 × 10–3 M), manganese activates K+ outflow from the erythrocytes but inhibits the valinomycin-induced outflow of the ion from the erythrocytes. This fact is an indication of manganese influence on physicochemical properties of membranes. At low concentrations manganese does not affect parameters of respiration and oxidative phosphorylation of rat liver mitochondria, while at high concentrations it exerts acceleration of the mitochondrial respiration, i.e., uncouples respiration from phosphorilation and, hence, inhibits ATP synthesis.

About the authors

M. S. Goncharenko

Karazin Kharkiv National University

Email: mironova40@mail.ru
Ukraine, pl. Svobody 4, Kharkiv, 61022

A. I. Tkachenko

Karazin Kharkiv National University

Email: mironova40@mail.ru
Ukraine, pl. Svobody 4, Kharkiv, 61022

N. V. Khmil

Karazin Kharkiv National University; Institute of Theoretical and Experimental Biophysics

Email: mironova40@mail.ru
Ukraine, pl. Svobody 4, Kharkiv, 61022; ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

S. M. Murzaeva

Pushchino State Institute of Natural Sciences

Email: mironova40@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

M. O. Korobeynikova

Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences

Email: mironova40@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

E. I. Lezhnev

Institute of Theoretical and Experimental Biophysics

Email: mironova40@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

O. V. Kolomytkin

Institute of Theoretical and Experimental Biophysics

Email: mironova40@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

G. D. Mironova

Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences

Author for correspondence.
Email: mironova40@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

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