Regulation of apoptotic signal by strontium in immunocytes

Abstract

Exposure to heavy metals can initiate the development of negative effects in different organs and systems, including the immune system, and can be manifested as dysfunction of receptor systems and intracellular signaling. The participation of stable strontium (Sr²⁺) in the regulation of apoptotic signals in immunocompetent cells was analyzed. Various mechanisms of strontium-induced modulation of the apoptotic lymphocyte reaction were described, and the formation of intracellular signal transduction involving Sr²⁺ was defined. The flow cytometry method was used to study changes in membrane and intracellular markers of apoptosis in children who consumed drinking water with the elevated levels of strontium. It was shown that the content of strontium in blood in the range of 0.0129–0.173 mg/dm³ affected different ways of apoptosis regulation (CD95-, p53-, and TNF-induced apoptosis) and their integration sites, thereby reducing the transmission of apoptotic signal in immunocompetent cells, and formed an alternative pathway of the cell elimination based on the mechanism of necrosis.