Cellular Mechanisms of Bioresorption of a Porous 3D Matrix Based on Chitosan
- 作者: Popryadukhin P.1,2, Yukina G.3,2, Dobrovolskaya I.1,2, Ivankova E.1,2, Yudin V.1,2
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隶属关系:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- Peter the Great St. Petersburg Polytechnic University
- Pavlov First Saint Petersburg State Medical University
- 期: 卷 13, 编号 6 (2019)
- 页面: 463-469
- 栏目: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/213037
- DOI: https://doi.org/10.1134/S1990519X19060087
- ID: 213037
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详细
Highly porous three-dimensional (3D) cylindrical matrices with a diameter of 1.3 mm were obtained by lyophilization of the chitosan solution. The matrix was implanted into rat muscle tissue and after12 months underwent complete resorption. Cellular mechanisms of matrix bioresorption were examined by histological and immunohistochemical methods in vivo after1, 2, 6, 12, 24, 36, and 48 weeks. The role of CD68+ cells, mainly giant multinucleated of foreign body cells, has been investigated. Chronic aseptic inflammation is not accompanied by the activation of mast cells. It shows the bioinertness of the matrix material and allows us to recommend this matrix for use in regenerative medicine, tissue engineering, and cell transplantology.
作者简介
P. Popryadukhin
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
编辑信件的主要联系方式.
Email: pavelpnru@gmail.com
俄罗斯联邦, St. Petersburg, 194064; St. Petersburg, 195251
G. Yukina
Pavlov First Saint Petersburg State Medical University; Peter the Great St. Petersburg Polytechnic University
Email: pavelpnru@gmail.com
俄罗斯联邦, St. Petersburg, 197376; St. Petersburg, 195251
I. Dobrovolskaya
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: pavelpnru@gmail.com
俄罗斯联邦, St. Petersburg, 194064; St. Petersburg, 195251
E. Ivankova
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: pavelpnru@gmail.com
俄罗斯联邦, St. Petersburg, 194064; St. Petersburg, 195251
V. Yudin
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: pavelpnru@gmail.com
俄罗斯联邦, St. Petersburg, 194064; St. Petersburg, 195251