Histogenesis Stages of Osteogenic Grafts in Culture Medium and a Recipient Bed
- Authors: Zaydman A.M.1, Shevchenko I.A.2, Strokova E.L.1, Gusev A.F.1,3, Pakhomova N.Y.1, Kirilova I.A.1, Rerikh V.V.1,3, Subbotin V.M.4,5
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Affiliations:
- Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan
- Institute of Cytology and Genetics, Russian Academy of Science
- Novosibirsk State Medical University
- Arrowhead Pharmaceuticals Corporation
- University of Pittsburgh
- Issue: Vol 13, No 5 (2019)
- Pages: 331-343
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212991
- DOI: https://doi.org/10.1134/S1990519X19050109
- ID: 212991
Cite item
Abstract
This paper describes the stages of osteogenic differentiation of chondrogenic graft in a culture medium and recipient bed (defect of bone tissue). In the culture medium, cell and matrix transformations, formation of vascular cavities with an endothelial lining and matrix vesicles in osteoblasts (the first stage of mineralization) take place in the chondrograft. The expression of chondrogenic genes and proteins is replaced by the expression of genes and proteins of the osteogenic stage of differentiation. Further stages of bone tissue histogenesis occur in the recipient bed. Humoral factors of regulation and ductile substance enter through the formed anastomosis of the vessels of osteodysplastica and recipient. On their basis, the formation of an organ-specific regenerate is completed with full integration into the recipient organism. These results are a starting point for further use of osteogenic grafts in clinical practice.
About the authors
A. M. Zaydman
Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan
Author for correspondence.
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630091
I. A. Shevchenko
Institute of Cytology and Genetics, Russian Academy of Science
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630090
E. L. Strokova
Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630091
A. F. Gusev
Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan; Novosibirsk State Medical University
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630091; Novosibirsk, 630091
N. Yu. Pakhomova
Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630091
I. A. Kirilova
Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630091
V. V. Rerikh
Novosibirsk Research Institute of Traumatology and Orthopedics Named after Ya.L. Tsivyan; Novosibirsk State Medical University
Email: AZaydman@niito.ru
Russian Federation, Novosibirsk, 630091; Novosibirsk, 630091
V. M. Subbotin
Arrowhead Pharmaceuticals Corporation; University of Pittsburgh
Email: AZaydman@niito.ru
United States, Madison WI, 53179; Pittsburgh PA, 15260