Infrared Spectroscopy of Blood Serum from Patients with Multiple Myeloma
- Authors: Plotnikova L.V.1, Kobeleva M.O.2, Borisov E.V.1, Garifullin A.D.3, Povolotskaya A.V.1, Voloshin S.V.3, Polyanichko A.M.1,4
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Affiliations:
- St. Petersburg State University
- St. Petersburg National Research University of Information Technologies, Mechanics and Optics
- Russian Scientific Institute of Hematology and Transfusiology
- Institute of Cytology, Russia Academy of Sciences
- Issue: Vol 13, No 2 (2019)
- Pages: 130-135
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212900
- DOI: https://doi.org/10.1134/S1990519X19020093
- ID: 212900
Cite item
Abstract
A combination of high-resolution agarose gel protein electrophoresis, refractometric analysis, and infrared spectroscopy was applied to investigate the blood serum in patients with multiple myeloma (MM). Analysis of the FTIR spectra of the serum obtained from MM patients and healthy donors revealed a decreased amount of α-helixes and increased content of β-sheets in serum proteins from MM patients compared to healthy donors. These findings suggest an interaction between serum proteins and stabilization of the resulting complexes, accompanied by the formation of associated β-sheets.
Keywords
About the authors
L. V. Plotnikova
St. Petersburg State University
Author for correspondence.
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 199034
M. O. Kobeleva
St. Petersburg National Research University of Information Technologies, Mechanics and Optics
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 197101
E. V. Borisov
St. Petersburg State University
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 199034
A. D. Garifullin
Russian Scientific Institute of Hematology and Transfusiology
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 191024
A. V. Povolotskaya
St. Petersburg State University
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 199034
S. V. Voloshin
Russian Scientific Institute of Hematology and Transfusiology
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 191024
A. M. Polyanichko
St. Petersburg State University; Institute of Cytology, Russia Academy of Sciences
Email: ljusja@mail.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 194064