Calculation of Na+/Cl− Selectivity in Tight Junctions between Epithelial Cells by Methods of Nonlocal Electrostatics with Pole Models of Dielectric Function without an Overscreening Effect
- Authors: Rubashkin A.A.1, Iserovich P.2
-
Affiliations:
- Institute of Cytology
- Downstate Medical Center
- Issue: Vol 12, No 4 (2018)
- Pages: 323-330
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212721
- DOI: https://doi.org/10.1134/S1990519X18040089
- ID: 212721
Cite item
Abstract
A mathematical model of Na+/Cl− selectivity in tight junctions (TJs) between epithelial cells was developed. It was demonstrated that Na+/Cl− selectivity in TJs depends on the total charge of amino-acid residues of claudin macromolecules within TJs, as well as on the ion-distribution coefficients between TJs and free solution. It was demonstrated that the obtained formulas predict a change of Na+/Cl− selectivity in TJs for Cl−/Na+ selectivity if the sign of the total charge of amino-acid residues in TJ changes. The calculated Na+/Cl− selectivity value for MDCK cells coincides with the experimental data of (Colegio et al., 2002). To calculate a change in ion-solvation energy during their transition to TJs, formulas for nonlocal electrostatics with one-, two-, and three-pole models of dielectric function without taking into account the overscreening effect were used.
About the authors
A. A. Rubashkin
Institute of Cytology
Author for correspondence.
Email: andrey.rubashkin@gmail.com
Russian Federation, St. Petersburg, 194064
P. Iserovich
Downstate Medical Center
Email: andrey.rubashkin@gmail.com
United States, New York, 11203