Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro
- Authors: Yurova K.A.1, Khaziakhmatova O.G.1, Dunets N.A.1, Todosenko N.M.1, Shupletsova V.V.1, Litvinova L.S.1
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Affiliations:
- Immanuel Kant Baltic Federal University
- Issue: Vol 11, No 5 (2017)
- Pages: 356-362
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212452
- DOI: https://doi.org/10.1134/S1990519X1705011X
- ID: 212452
Cite item
Abstract
The effect of cytokines (IL-2, IL-7, and IL-15) having a common γ-chain of receptors on the maturation and differentiation of CD3+CD45RA+CD4+/CD8+ lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA+-T-cell population mediates an increase in the number of CD45RA+CD4+ T lymphocytes with the phenotype of mature and immature terminally differentiated TEMRA T cells. IL-15 leads to the production of lymphocytes with CD27–CD62L+ phenotype (presumably, TEMRA, in which the CD62L expression persists). In the CD45RA+CD8+ T lymphocyte populations, the studied cytokines (IL-2, IL-7, and IL-15) initiate the production of mature TEMRA (E) T lymphocytes and memory T cells with the CD45RA−CD27+CD62L+ central phenotype (TCM).
About the authors
K. A. Yurova
Immanuel Kant Baltic Federal University
Email: larisalitvinova@yandex.ru
Russian Federation, Kaliningrad, 236016
O. G. Khaziakhmatova
Immanuel Kant Baltic Federal University
Email: larisalitvinova@yandex.ru
Russian Federation, Kaliningrad, 236016
N. A. Dunets
Immanuel Kant Baltic Federal University
Email: larisalitvinova@yandex.ru
Russian Federation, Kaliningrad, 236016
N. M. Todosenko
Immanuel Kant Baltic Federal University
Email: larisalitvinova@yandex.ru
Russian Federation, Kaliningrad, 236016
V. V. Shupletsova
Immanuel Kant Baltic Federal University
Email: larisalitvinova@yandex.ru
Russian Federation, Kaliningrad, 236016
L. S. Litvinova
Immanuel Kant Baltic Federal University
Author for correspondence.
Email: larisalitvinova@yandex.ru
Russian Federation, Kaliningrad, 236016