Мақаланы E-mail арқылы жіберу Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A
- Авторлар: Stepanichev M.Y.1, Markov D.A.1, Freiman S.V.1, Frolova O.A.1, Omelyanchik S.N.2, Borodina T.A.2, Novikova M.R.1, Kanunnikova N.P.3, Onufriev M.V.1, Moiseenok A.G.2, Gulyaeva N.V.1
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Мекемелер:
- Institute of Higher Nervous Activity and Neurophysiology
- Institute of Biochemistry of Biologically Active Compounds
- Grodno State Medical University
- Шығарылым: Том 10, № 2 (2016)
- Беттер: 120-130
- Бөлім: Experimental Articles
- URL: https://journals.rcsi.science/1819-7124/article/view/211038
- DOI: https://doi.org/10.1134/S1819712416020094
- ID: 211038
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Free-radical-mediated processes are involved in a variety of physiological events, while oxidative stress and related redox deregulation are implicated in various pathological events. Tripeptide glutathione plays an important role in the antioxidant defense of the brain, particularly in the maintenance of the optimal redox state in neurons and glial cells. We studied the combined effects of pantothenic acid derivatives, pantothenol and calcium pantothenate, and memantine, which is a glutamate receptor antagonist that is widely used for the treatment of dementia, on amnesia induced by scopolamine in rats. Scopolamine induced amnesia in rats; however, unexpectedly, this effect was even more expressed in the memantine-pretreated animals. Memory impairments were less manifested in the rats that were pretreated with memantine in combination with panthenol or calcium pantothenate. The detrimental scopolamine effect on memory was accompanied by significant depletions of glutathione and coenzyme A in the brain. While memantine recovered the glutathione status to some extent, it nevertheless further aggravated the scopolamine influence on coenzyme A levels. An alleviation of scopolamine-induced memory impairments that was observed after combined pretreatment with memantine and panthenol or calcium pantothenate was accompanied by a normalization of coenzyme A levels, while the effects on glutathione redox did not correlate with the behavioral data.
Авторлар туралы
M. Stepanichev
Institute of Higher Nervous Activity and Neurophysiology
Email: nata_gul@pisem.net
Ресей, Moscow
D. Markov
Institute of Higher Nervous Activity and Neurophysiology
Email: nata_gul@pisem.net
Ресей, Moscow
S. Freiman
Institute of Higher Nervous Activity and Neurophysiology
Email: nata_gul@pisem.net
Ресей, Moscow
O. Frolova
Institute of Higher Nervous Activity and Neurophysiology
Email: nata_gul@pisem.net
Ресей, Moscow
S. Omelyanchik
Institute of Biochemistry of Biologically Active Compounds
Email: nata_gul@pisem.net
Белоруссия, Grodno
T. Borodina
Institute of Biochemistry of Biologically Active Compounds
Email: nata_gul@pisem.net
Белоруссия, Grodno
M. Novikova
Institute of Higher Nervous Activity and Neurophysiology
Email: nata_gul@pisem.net
Ресей, Moscow
N. Kanunnikova
Grodno State Medical University
Email: nata_gul@pisem.net
Белоруссия, Grodno
M. Onufriev
Institute of Higher Nervous Activity and Neurophysiology
Email: nata_gul@pisem.net
Ресей, Moscow
A. Moiseenok
Institute of Biochemistry of Biologically Active Compounds
Email: nata_gul@pisem.net
Белоруссия, Grodno
N. Gulyaeva
Institute of Higher Nervous Activity and Neurophysiology
Хат алмасуға жауапты Автор.
Email: nata_gul@pisem.net
Ресей, Moscow
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