One-Carbon Metabolism Disorders in Schizophrenia: Genetic and Therapeutic Aspects

Resumo

We review the role of disorders of one-carbon metabolism (OCM) in the etiopathogenesis of schizophrenia, define directions for further research into the role of single nucleotide genetic polymorphisms of the folate pathway enzymes, and outlined future lines of studies on personalized correction of OCM disorders. The reviewed data suggest that it is necessary to perform complex studies on the genetic risk of OCM disorders, molecular mechanisms of schizophrenia pathogenesis, which involve OCM disorders, and the clinical effects of their personalized correction.