The Effect of Lithium Chloride on the Levels of Brain-Derived Neurotrophic Factor in the Neonatal Brain
- 作者: Bannova A.1, Menshanov P.1,2, Dygalo N.1,3
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隶属关系:
- Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State Technical University
- Novosibirsk State University
- 期: 卷 13, 编号 4 (2019)
- 页面: 344-348
- 栏目: Experimental Articles
- URL: https://journals.rcsi.science/1819-7124/article/view/211780
- DOI: https://doi.org/10.1134/S1819712419030048
- ID: 211780
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详细
Abstract—The brain-derived neurotrophic factor BDNF, which regulates neurogenesis and brain plasticity, mediates the neuroprotective action of the mood stabilizer lithium, which is commonly used in psychiatry. However, it remains unclear whether lithium affects BDNF levels in neonatal brain structures that differ in the maturity levels during ontogeny. Here, we studied the acute effects of lithium chloride (LiCl) treatment on the BDNF levels and levels of the apoptosis marker active caspase-3 in the brainstem and cortex of 3-day-old rats. Lithium increased the BDNF levels in both the brainstem and cortex of rat pups 2 h after injection. In the brainstem, which is more developed at postnatal day 3 in comparison to the cortex, the lithium-induced increase in the BDNF levels was accompanied by a 2-fold decrease in the levels of active caspase-3. These results show that the neuroprotective effects of LiCl treatment in the developing mammalian brain depend on the maturity level of the neonatal brain regions that are affected by the mood stabilizer.
作者简介
A. Bannova
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: anitik1979@gmail.com
俄罗斯联邦, pr. Akademika Lavrent’eva 10, Novosibirsk, 630090
P. Menshanov
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Novosibirsk State Technical University
Email: anitik1979@gmail.com
俄罗斯联邦, pr. Akademika Lavrent’eva 10, Novosibirsk, 630090; Novosibirsk
N. Dygalo
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: anitik1979@gmail.com
俄罗斯联邦, pr. Akademika Lavrent’eva 10, Novosibirsk, 630090; Novosibirsk