Afobazole Restores the Dopamine Level in a 6-Hydroxydopamine Model of Parkinson’s Disease

Abstract

In this study, 5 µg of 6-hydroxydopamine (6-OHDA) were injected unilaterally into the striatum of mice. The mice were then treated intraperitoneally with afobazole at a dose of 2.5 mg/kg for 14 days starting 30 min after the 6-OHDA injection. The content of monoamines was studied in the striatum of the mice. Afobazole prevented a decrease in the dopamine level in the 6-OHDA-damaged striatum of the experimental animals and did not affect the contents of norepinephrine, serotonin, or its metabolites in the striatum of both the control and 6-OHDA-treated mice.