The activities of basic carboxypeptidases in the nervous system of rats during exercise stress and in response to semax and selank

Abstract

The effects of exercise stress following single semax and selank administration on the activity of carboxypeptidase E and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase, which are basic carboxypeptidases that are involved in the final stage of processing of biologically active neuropeptide precursors, was studied. The enzyme activity was shown to increase during exercise stress, as well as in response to administration of the peptide agents prior to exercise. The role of basic carboxypeptidases in the mechanisms of semax- and selank-induced stimulation and in the activation of the peptidergic system during physical exercise is discussed.