Investigation of the process of recrystallization calcium carbonate microparticles grown on polycaprolactone nanofibers using scanning electron microscopy and X-ray diffraction

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Abstract

Background and Objectives: A method for the mineralization of polycaprolactone nanofibers with microparticles of calcium carbonate (vaterite) is presented. The proposed composite material can be used as a tissue engineering scaffold and a drug delivery vehicle for regenerative medicine. Materials and Methods: The process of recrystallization of vaterite microparticles formed on polycaprolactone fibers into calcite is studied using scanning electron microscopy and X-ray diffraction. Results: The dependences of the mass and quantitative fractions of vaterite/calcite microparticles depending on the duration of the experiment have been compared. Conclusion: The total recrystallization time for vaterite microparticles with an average diameter of 1.2 ± 0.4 microns is 24 hours, and the effective time of their use as a container for targeted drug delivery is limited to 18 hours.

About the authors

Nikita Vladimirovich Koronevskiy

Saratov State University

410012, Russia, Saratov, Astrakhanskaya street, 83

Olga Aleksandrovna Inozemtseva

Saratov State University

410012, Russia, Saratov, Astrakhanskaya street, 83

Bela V. Sergeeva

Saratov State University

410012, Russia, Saratov, Astrakhanskaya street, 83

Arseniy V. Ushakov

Saratov State University

410012, Russia, Saratov, Astrakhanskaya street, 83

Sergey Alekseevich Sergeev

Saratov State University

410012, Russia, Saratov, Astrakhanskaya street, 83

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