Regorafenib in metastatic colorectal cancer: more data for clinical decisions

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Regorafenib is a multiple kinase inhibitor. It influences/blocks angiogenesis (VEGFR1-3, TIE2), proliferation (KIT, RET, RAF-1, BRAF), metastatic activity (VEGFR2-3, PDGFR), tumor immunogenicity (CSF1R), tumor microenvironment (PDGFR-α, PDGFR-β, FGFR1-2). Regorafenib has several indications including metastatic colorectal cancer. Efficacy and safety of regorafenib data from clinical trials (CORRECT, CONCUR, CONSIGN) and observational trials from real world (REBECCA, CORRELATE, RECORA, PMS, REGOTAS) are summarized and presented in this issue. State of the matter of molecular-biologic predictors (KRAS, PIK3CA ANG-2, VEGF-A, LDH, CCL5/CCR5, CA 19-9) and radiological predictors (RadioCORRECT and other trials) is highlighted. Regimens with dose modification and its influence on effectiveness and tolerability of regorafenib are described according to the data from ReDOS, RESET, REARRANGE trials. The results from retrospective trials comparing regorafenib and another approved for refractory metastatic colorectal cancer drug trifluridine/tipiracil are presented.

作者简介

Vladislav Petkau

Ural State Medical University

编辑信件的主要联系方式.
Email: vpetkau@yandex.ru
ORCID iD: 0000-0002-0342-4007
SPIN 代码: 6811-8136

Cand. Sci. (Med.)

俄罗斯联邦, Ekaterinburg

Alisa Karimova

Ural State Medical University

Email: alice-k2006@yandex.ru
ORCID iD: 0000-0003-3500-096X
SPIN 代码: 8420-9600

Cand. Sci. (Pharm.)

俄罗斯联邦, Ekaterinburg

Zinaida Akishina

Perm Regional Oncological Dispensary

Email: zvakishina@list.ru

Deputy Chief Doctor

俄罗斯联邦, Perm

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