Регорафениб в лечении метастатического колоректального рака: больше данных для принятия решений
- Авторы: Петкау В.В.1, Каримова А.А.1, Акишина З.В.2
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Учреждения:
- ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
- ГБУЗ Пермского края «Пермский краевой онкологический диспансер»
- Выпуск: Том 23, № 3 (2021)
- Страницы: 436-441
- Раздел: КЛИНИЧЕСКАЯ ОНКОЛОГИЯ
- URL: https://journals.rcsi.science/1815-1434/article/view/83038
- DOI: https://doi.org/10.26442/18151434.2021.3.201130
- ID: 83038
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Регорафениб – мультитаргетный ингибитор тирозинкиназ, оказывающий влияние на ангиогенез (VEGFR1-3, TIE2), пролиферацию (KIT, RET, RAF-1, BRAF), метастазирование (VEGFR2-3, PDGFR), опухолевую иммуногенность (CSF1R), микроокружение опухоли (PDGFR-α, PDGFR-β, FGFR1-2). Регорафениб зарегистрирован по нескольким показаниям, в том числе для лечения метастатического колоректального рака. В статье представлены и обобщены данные по эффективности и профилю безопасности препарата, полученные как в клинических исследованиях III фазы (CORRECT, CONCUR, CONSIGN), так и в наблюдательных исследованиях в реальной клинической практике (REBECCA, CORRELATE, RECORA, PMS, REGOTAS). Рассмотрено изучение предикторов ответа, как молекулярно-биологических (KRAS, PIK3CA ANG-2, VEGF-A, ЛДГ, CCL5/CCR5, CA 19-9), так и рентгенологических (исследование RadioCORRECT и др.). Представлены варианты дозирования на основании исследований ReDOS, RESET, REARRANGE. Изучены данные ретроспективных исследований по сравнению регорафениба с другим зарегистрированным для рефрактерного метастатического колоректального рака препаратом трифлуридин/типирацил.
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Владислав Владимирович Петкау
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
Автор, ответственный за переписку.
Email: vpetkau@yandex.ru
ORCID iD: 0000-0002-0342-4007
SPIN-код: 6811-8136
канд. мед. наук, доц. каф. онкологии и лучевой диагностики
Россия, ЕкатеринбургАлиса Алексеевна Каримова
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
Email: alice-k2006@yandex.ru
ORCID iD: 0000-0003-3500-096X
SPIN-код: 8420-9600
канд. фарм. наук, ассистент каф. управления и экономики фармации, фармакогнозии
Россия, ЕкатеринбургЗинаида Васильевна Акишина
ГБУЗ Пермского края «Пермский краевой онкологический диспансер»
Email: zvakishina@list.ru
зам. глав. врача по амбулаторно-поликлинической работе, гл. онколог Минздрава Пермского края, засл. врач РФ
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