Регорафениб в лечении метастатического колоректального рака: больше данных для принятия решений

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Регорафениб – мультитаргетный ингибитор тирозинкиназ, оказывающий влияние на ангиогенез (VEGFR1-3, TIE2), пролиферацию (KIT, RET, RAF-1, BRAF), метастазирование (VEGFR2-3, PDGFR), опухолевую иммуногенность (CSF1R), микроокружение опухоли (PDGFR-α, PDGFR-β, FGFR1-2). Регорафениб зарегистрирован по нескольким показаниям, в том числе для лечения метастатического колоректального рака. В статье представлены и обобщены данные по эффективности и профилю безопасности препарата, полученные как в клинических исследованиях III фазы (CORRECT, CONCUR, CONSIGN), так и в наблюдательных исследованиях в реальной клинической практике (REBECCA, CORRELATE, RECORA, PMS, REGOTAS). Рассмотрено изучение предикторов ответа, как молекулярно-биологических (KRAS, PIK3CA ANG-2, VEGF-A, ЛДГ, CCL5/CCR5, CA 19-9), так и рентгенологических (исследование RadioCORRECT и др.). Представлены варианты дозирования на основании исследований ReDOS, RESET, REARRANGE. Изучены данные ретроспективных исследований по сравнению регорафениба с другим зарегистрированным для рефрактерного метастатического колоректального рака препаратом трифлуридин/типирацил.

Об авторах

Владислав Владимирович Петкау

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России

Автор, ответственный за переписку.
Email: vpetkau@yandex.ru
ORCID iD: 0000-0002-0342-4007
SPIN-код: 6811-8136

канд. мед. наук, доц. каф. онкологии и лучевой диагностики

Россия, Екатеринбург

Алиса Алексеевна Каримова

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России

Email: alice-k2006@yandex.ru
ORCID iD: 0000-0003-3500-096X
SPIN-код: 8420-9600

канд. фарм. наук, ассистент каф. управления и экономики фармации, фармакогнозии

Россия, Екатеринбург

Зинаида Васильевна Акишина

ГБУЗ Пермского края «Пермский краевой онкологический диспансер»

Email: zvakishina@list.ru

зам. глав. врача по амбулаторно-поликлинической работе, гл. онколог Минздрава Пермского края, засл. врач РФ

Россия, Пермь

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