Metastatic gastrointestinal stromal tumor of the greater omentum. Case report
- 作者: Yugay V.1, Nikulin M.1,2, Mazurenko N.1, Mochal'nikova V.1, Filonenko D.3, Meshherjakov A.1, Bugaev V.1, Arhiri P.1,4, Stroganova A.1, Stilidi I.1,4,5
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隶属关系:
- Blokhin National Medical Research Center of Oncology
- Yevdokimov Moscow State University of Medicine and Dentistry
- Loginov Moscow Clinical Scientific Center
- Russian Medical Academy of Continuous Professional Education
- Pirogov Russian National Research Medical University
- 期: 卷 23, 编号 4 (2021)
- 页面: 680-684
- 栏目: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/76385
- DOI: https://doi.org/10.26442/18151434.2021.4.201222
- ID: 76385
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Gastrointestinal stromal tumors (GIST) are the most common type of mesenchymal malignancies of the gastrointestinal (GI) tract. Almost 10% of them are originated outside of the GI tract (extra-GIST), while GIST of the greater omentum constitutes about 1% among stromal tumors. More than 80% of GIST have mutations in c-KIT and PDGFRA genes. Herein we demonstrate the case of successful treatment of patient with giant omental GIST with c-KIT exon 11 mutation. 64-years-old woman, was admitted to the Department of abdominal oncology with complaints of shortness of breath and abdominal enlargement in volume. CT-scan revealed a large tumor in the abdominal cavity with tumor size of 54×34×22 cm. The patient underwent left thoraco-abdominal approach. It was found that the tumor was originated from the greater omentum with several metastases located on the peritoneum of the left lateral channel. Resection of the large omentum, splenectomy, liver resection and was done. Postoperative immunohistochemical study showed the expression of CD117, CD34 in tumor cells. Ki-67 index was 12–15%. Genetic study revealed c-KIT exon 11 mutation. Treatment with imatinib 400 mg per day was started. Patient has been treated with imatinib for 12 years. On control examination we have found a metastasis in the anterior abdominal wall 3,5×3×2,5 cm in diameter. Afterwards we performed resection of anterior abdominal wall with metastasis on 9 November 2017. Immunohistochemical study confirmed metastasis of GIST. The index of tumor proliferation activity (Ki-67) was 45%. Patient prolonged imatinib treatment at the dose of 400 mg per day after operation. No signs of progression have been revealed on control examination 72 months after the operation. 12-year progression-free survival during imatinib treatment is unique in our practice. Moreover, in the case of further progression, we have second and third-line targeted therapy (sunitinib and regorafenib) and surgery treatment in local progression.
作者简介
Vladimir Yugay
Blokhin National Medical Research Center of Oncology
编辑信件的主要联系方式.
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0001-6169-2723
SPIN 代码: 2271-3639
oncologist
俄罗斯联邦, MoscowMaxim Nikulin
Blokhin National Medical Research Center of Oncology; Yevdokimov Moscow State University of Medicine and Dentistry
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0002-9608-4696
SPIN 代码: 9455-5566
Cand. Sci. (Med.)
俄罗斯联邦, MoscowNatalya Mazurenko
Blokhin National Medical Research Center of Oncology
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0003-4767-6983
SPIN 代码: 9169-8910
D. Sci. (Biol.), Prof.
俄罗斯联邦, MoscowValerija Mochal'nikova
Blokhin National Medical Research Center of Oncology
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0001-5275-7134
SPIN 代码: 7131-1273
pathologist
俄罗斯联邦, MoscowDar'ja Filonenko
Loginov Moscow Clinical Scientific Center
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0002-7224-3111
Cand. Sci. (Med.)
俄罗斯联邦, MoscowAndrey Meshherjakov
Blokhin National Medical Research Center of Oncology
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0002-6009-653X
SPIN 代码: 3987-0910
D. Sci. (Med.)
俄罗斯联邦, MoscowVladislav Bugaev
Blokhin National Medical Research Center of Oncology
Email: yugay_vladimir@mail.ru
SPIN 代码: 7913-4919
Cand. Sci. (Med.)
俄罗斯联邦, MoscowPetr Arhiri
Blokhin National Medical Research Center of Oncology; Russian Medical Academy of Continuous Professional Education
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0002-6791-2923
SPIN 代码: 6880-4902
Cand. Sci. (Med.)
俄罗斯联邦, MoscowAnna Stroganova
Blokhin National Medical Research Center of Oncology
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0002-7297-5240
SPIN 代码: 5295-3338
Cand. Sci. (Med.)
俄罗斯联邦, MoscowIvan Stilidi
Blokhin National Medical Research Center of Oncology; Russian Medical Academy of Continuous Professional Education; Pirogov Russian National Research Medical University
Email: yugay_vladimir@mail.ru
ORCID iD: 0000-0002-0493-1166
SPIN 代码: 9622-7106
D. Sci. (Med.), Prof., Acad. RAS
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