Clinical case of long-term use of durvalumab in the treatment of advanced small-cell lung cancer
- 作者: Statsenko G.1, Kurakin V.1, Plokhotenko I.1
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隶属关系:
- Omsk Regional Clinical Oncology Dispensary
- 期: 卷 22, 编号 2 (2020)
- 页面: 112-115
- 栏目: Clinical Case
- URL: https://journals.rcsi.science/1815-1434/article/view/34963
- DOI: https://doi.org/10.26442/18151434.2020.2.200222
- ID: 34963
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详细
Over the last few decades there was a little progress in the treatment of small cell lung cancer (SCLC). But now the approaches are changing with immune checkpoint inhibitors coming into clinical practice. Using a combination of immunotherapy with the standard chemotherapy in the first line of extensive stage small cell lung cancer (ES-SCLC) results in significant overall survival improvement, for the first time the median survival in these patients exceeded one year. Here we present a clinical case of ES-SCLC patient treated with durvalumab, a monoclonal antibody against PD-L1, in combination with etoposide and carboplatin in the CASPIAN clinical trial. In the CASPIAN trial more than 20% of patients treated with durvalumab stay alive more than two years. In the presented case we also reported durable control of the disease, the patient continued to receive durvalumab of more than two years with acceptable tolerability.
作者简介
Galina Statsenko
Omsk Regional Clinical Oncology Dispensary
编辑信件的主要联系方式.
Email: galina.stacenko.00@mail.ru
ORCID iD: 0000-0001-7123-8639
deputy chief physician
俄罗斯联邦, OmskVyacheslav Kurakin
Omsk Regional Clinical Oncology Dispensary
Email: KurakinVI@mail.ru
ORCID iD: 0000-0002-6580-9607
Chief of Chemotherapy Department №1
俄罗斯联邦, OmskIrina Plokhotenko
Omsk Regional Clinical Oncology Dispensary
Email: plokirina@yandex.ru
ORCID iD: 0000-0002-1257-1586
thoracic oncologist of the polyclinic
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