Neuroendocrine carcinoma of the prostate (review of the literature)

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Neuroendocrine neoplasia (NEC) of the prostate gland is a rather rare extrapulmonary neuroendocrine carcinoma and makes up only 0.5 to 1% of all malignant neoplasms of this localization. NEC of the prostate gland is a tumor of epithelial origin, histologically and immunohistochemically identical to analogues in the lungs and digestive system. When stained with hemotoxylin-eosin, neuroendocrine cells cannot always be visualized; they are best recognized by the immunohistochemical method of investigation using specific markers. Currently, a number of neuroendocrine markers are used, the expression of which may indicate a neuroendocrine nature. Androgen neuroendocrine cells themselves are independent and do not cause an increase in the concentration of prostate-specific antigen. Prostate NECs are represented by some histological forms according to WHO classification (2015): 1. Adenocarcinoma with focal neuroendocrine differentiation. 2. Well-differentiated neuroendocrine tumor. 3. Small cell neuroendocrine cancer is a high - grade tumor with high malignant potential. 4. Large cell neuroendocrine cancer is a high - grade tumor. Due to the rarity of NEC of the prostate, a specific algorithm for diagnosis and treatment has not been developed, as a rule, they are similar to methods of other malignant forms of prostate cancer and neuroendocrine tumors.

作者简介

Daria Abbasova

Sechenov First Moscow State Medical University (Sechenov University)

Email: dariaabbasova@yandex.ru
Graduate Student, S Moscow, Russia

Svetlana Polikarpova

Sechenov First Moscow State Medical University (Sechenov University)

Email: svetac@mail.ru
д-р мед. наук, проф. каф. онкологии лечебного фак-та Moscow, Russia

Nikolai Kozlov

Blokhin National Medical Research Center of Oncology

Cand. Sci. (Med.) Moscow, Russia

Madina Baranova

Russian Medical Academy of Continuous Professional Education

Email: protokosha@yandex.ru
Cand. Sci. (Med.) Moscow, Russia

Irina Kovalenko

Blokhin National Medical Research Center of Oncology

Cand. Sci. (Med.) Moscow, Russia

Elena Ignatova

Blokhin National Medical Research Center of Oncology

Cand. Sci. (Med.) Moscow, Russia

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