Pre-operative chemoradiation therapy in complex treatment of patients with locally advanced tumors of the thoracic esophagus

M S Shogenov; Шогенов Мурат Сергеевич; M M Davydov; Давыдов Михаил Михайлович; A K Allakhverdiyev; Аллахвердиев Ариф Керимович; A K Chekini; Чекини Антонио Константинович; A A Filatov; Филатов Антон Александрович; P I Akhmedov; Ахмедов Парвин Илгарович; M V Serebryanskaya; Серебрянская Марина Вячеславовна; A A Korolyeva; Королева Анна Анатольевна; I A Dadyev; Дадыев Ислам Артурович; E I Chichikov; Чичиков Евгений Игоревич; V A Grigorenko; Григоренко Василий Андреевич; N A Kozlov; Козлов Николай Александрович; P B Nazliyev; Назлиев Павел Борисович; O A Malikhova; Малихова Ольга Александровна; A A Tryakin; Трякин Алексей Александрович

Pre-operative chemoradiation therapy in complex treatment of patients with locally advanced tumors of the thoracic esophagus

作者: Shogenov M¹, Davydov M¹, Allakhverdiyev A¹, Chekini A¹, Filatov A¹, Akhmedov P¹, Serebryanskaya M¹, Korolyeva A¹, Dadyev I¹, Chichikov E¹, Grigorenko V¹, Kozlov N¹, Nazliyev P¹, Malikhova O¹, Tryakin A¹
隶属关系:
1. N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
期: 卷 20, 编号 1 (2018)
页面: 50-53
栏目: Articles
URL: https://journals.rcsi.science/1815-1434/article/view/27170
ID: 27170

如何引用文章

全文:

详细
全文:
作者简介
参考
统计

详细

The objective of this study was to evaluate the preliminary results of the complex treatment of patients with locally advanced tumors of the thoracic esophagus after pre-operative chemordiation therapy. Materials and methods. Men and women (n=26) over 18 years of age with histologically squamous cell carcinoma tumors T3-4aN0-3M0 of the thoracic esophagus were included in our study. In this group of patients we performed pre-operative chemotherapy: paklitaxel 175 mg/м2 first day; cisplatin 75 mg/м2 first day; leucovorin 50 mg 1-3 days; 5-ftoruracil 425 mg/м2 1-3 days or instead of leucovorin and 5-ftoruracil we used capecitabine 1500 mg/м2 1-14 days, every 3 weeks followed by chemoradiation therapy (РОД 2 Gy, СОД 44-46 Gy) with weekly used of chemotherapy. We analyzed the preliminary results of the complex treatment in terms of the severity of toxicity, therapeutic pathomorphosis and reduction in the tumor stage and the number of postoperative complications. R0-resections were performed in 24 (92%) patients. Microscopic manifestations of the tumor in the proximal margin of resection (R1) were detected only in 2 (8%) patients. Therapeutic pathomorphosis was studied in all 26 patients. In the histological study, 8 (31%) patients did not have tumor cells, which was regarded as the complete effect of chemotherapy in the preoperative period. Pathomorphosis of grade 3 was observed in 9 patients, which was 35%. Thus, the used strategy of preoperative chemotherapy and chemoradiotherapy is a promising direction in improving long-term treatment outcomes.

关键词

locally advanced tumors of the esophagus, complex treatment of the esophagus cancer, induction chemotherapy, therapeutic (curative) pathomorphosis

全文:

##article.viewOnOriginalSite##

参考

Ferlay J, Shin H.R, Bray F et al. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer 2010; 127: 2893-917.
Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2012 году: заболеваемость и смертность. М.: МНИОИ им. П.А. Герцена, 2014.
Trivers K.F, Sabatino S.A, Stewart S.L. Trends in esophageal cancer incidence by histology, United States, 1998-2003. Int J Cancer 2008; 123: 1422-8.
Devesa S.S, Blot W.J, Fraumeni J.F. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998; 83: 2049-53.
Steevens J, Botterweck A.A.M, Dirx M.J.M et al. Trends in incidence of oesophageal and stomach cancer subtypes in Europe. Eur J Gastroenterol Hepatol 2010; 22: 669-78.
Hongo M, Nagasaki Y, Shoji T. Epidemiology of esophageal cancer: Orient to Occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol 2009; 24: 729-35.
Muller J.M, Erasmi H, Stelzner M, Pichlmaier U. Surgical therapy of oesophageal carcinoma. Br J Surg 1990; 77: 845-57.
Rice T.W, Blackstone E.H, Rusch V.W. 7th edition of the AJCC cancer staging manual: Esophagus and esophagogastric junction. Ann Surg Oncol 2010; 17: 1721-4.
Pennathur A et al. Esophagectomy for T1 esophageal cancer: Outcomes in 100 patients and implications for endoscopic therapy. Ann Thorac Surg 2009; 87: 1048-54.
Cooper J et al. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA 1999; 281 (17): 1623-7.
Wang D.B, Zhang X, Han H.L et al. Neoadjuvant chemoradiotherapy could improve survival outcomes for esophageal carcinoma: a meta-analysis. Digestive Dis Sci 2012; 57: 3226-33.
Kranzfelder M, Schuster T, Geinitz H et al. Meta-analysis of neoadjuvant treatment modalities and definitive non-surgical therapy for oesophageal squamous cell cancer. Brit J Surg 2011; 98: 768-83.
Shapiro J, van Lanschot J.J, Hulshof M.C. et al. CROSS study group. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol 2015; 16 (9): 1090-8.
Cao X.F, He X.T, Ji L et al. Effects of neoadjuvant radiochemotherapy on pathological staging and prognosis for locally advanced esophageal squamous cell carcinoma. Dis Esoph 2009; 22: 477-81.
Urba S.G, Orringer M.B, Turrisi A et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001; 19: 305-13.

用户名
密码
记住我

忘记您的密码?	注册

用户名
密码
记住我

忘记您的密码?	注册

Pre-operative chemoradiation therapy in complex treatment of patients with locally advanced tumors of the thoracic esophagus

全文:

详细

关键词

全文:

作者简介

M Shogenov

M Davydov

A Allakhverdiyev

A Chekini

A Filatov

P Akhmedov

M Serebryanskaya

A Korolyeva

I Dadyev

E Chichikov

V Grigorenko

N Kozlov

P Nazliyev

O Malikhova

A Tryakin

参考