The choice of treatment method in patients with complicated gastrointestinal stromal tumors. Clinical observation and literature review


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Gastrointestinal stromal tumors (GISTs) can be complicated with gastrointestinal bleeding, ileus, gastrointestinal perforation at the site of tumor, spontaneous intraabdominal bleeding because of ruptured GIST and the formation of necrotic cavities in the tumor communicated with the lumens of hollow organs. Common practice in such cases is combined use of surgery with imatinib treatment. The article deals with the data of literature review concerning the incidence and clinical characteristics of complications in patients with different tumors. We showed the clinical study, where imatinib therapy was used as the first part of the treatment patients with luminal GIST of the stomach, complicated with gastric bleeding. Neoadjuvant therapy had significantly reduced tumor sizes; improved the condition of the patient and helped us to perform surgery.

作者简介

S Nered

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

д-р мед. наук, вед. науч. сотр. отд-ния абдоминальной онкологии торако-абдоминального отд. ФГБУ «РОНЦ им. Н.Н.Блохина»; доц. каф. онкологии ФГБОУ ДПО РМАНПО 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23; 123995, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

I Stilidi

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

чл.-кор. РАН, д-р мед. наук, проф., зав. отд-нием абдоминальной онкологии торако-абдоминального отд. ФГБУ «РОНЦ им. Н.Н.Блохина»; проф. каф. онкологии ФГБОУ ДПО РМАНПО 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23; 123995, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

V Shalenkov

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation

Email: do71@yandex.ru
канд. мед. наук, науч. сотр. отд-ния абдоминальной онкологии торако-абдоминального отд. ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

P Arkhiri

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

канд. мед. наук, хирург-онколог отд-ния абдоминальной онкологии торако-абдоминального отдела ФГБУ «РОНЦ им. Н.Н.Блохина»; ассистент каф. онкологии ФГБОУ ДПО РМАНПО 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23; 123995, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

I Perfilev

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation

канд. мед. наук, врач-эндоскопист, отд-ния эндоскопии ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

A Kalinin

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation

канд. мед. наук, хирург-онколог отд-ния абдоминальной онкологии торако-абдоминального отд. ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

Ya Bozhchenko

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation

врач-патологоанатом, отд-ния патологической анатомии опухолей человека ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

E Glukhov

N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation

канд. мед. наук, науч. сотр. отд-ния абдоминальной онкологии торако-абдоминального отд. ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

参考

  1. Eisenberg B.L, Harris J, Blanke C.D et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST). J Surg Oncol 2009; 99: 42-7.
  2. Hohenberger P, Langer C, Wendtner C.M et al. Neoadjuvant treatment of locally advanced GIST: Results of APOLLON, a prospective, open label phase II study in KIT - or PDGFRA - positive tumors. J Clin Oncol 2012; 30: 10031.
  3. Rutkowski P, Gronchi A, Hohenberger P et al. Neoadjuvant imatinib in locally advanced gastrointestinal stromal tumors (GIST): the EORTC STBSG experience. Ann Surg Oncol 2013; 20 (9): 2937-43.
  4. Sorour M.A, Kassem M.I, Ghazal A.A et al. Gastrointestinal stromal tumors (GIST) related emergencies. Int J Surgery 2014; 12: 269-80.
  5. Mokhtare M, Taghvaei T, Tirgar Fakheri H. Acute Bleeding In Duodenal Gastrointestinal Stromal Tumor. Middle East J Dig Dis 2013; 5: 47-51.
  6. Vilallonga R, Sanchez J.L, Armengol M. Gastrointestinal Stromal Tumor: Cause of Gastrointestinal Bleeding. Gastroenterology Research 2010; 3 (2): 93-5.
  7. Lee G.W, Kim Y.S, Kim S.G et al. Spontaneous Rupture of a Gastric Stromal Tumor Causing Hemoperitoneum. Gut and Liver 2010; 4 (2): 278-82.
  8. Mohamed A, Griffiths E, Witkowski M et al. Traumatic rupture of a gastrointestinal stromal tumour with intraperitoneal bleeding and haematoma formation. BMJ Case Reports 2010; doi: 10.1136/bcr.12.2009.2541
  9. Tateno Y, Suzuki R. Spontaneous Hemoperitoneum Because of a Ruptured GIST without Abdominal Pain. Clin Surg 2016; 1: 1004.
  10. Agrawal V.P, Wasnik N, Yede J, Gupta A. Perforation of gastric gastrointestinal stromal tumor: A rare phenomenon & review of literature. Int J Biomedical Adv Res 2014; 5 (10): 485-7.
  11. Paramythiotis D, Panidis S, Papadopoulos V et al. Perforated Gastrointestinal Stromal Tumor of the Small Intestine: A Case Report Presenting With Peritonitis. J Curr Surg 2011; 1 (1): 44-6.
  12. Skipworth J.R.A, Fanshawe A.E.E, West M.J, Al-Bahrani A. Perforation as a rare presentation of gastric gastrointestinal stromal tumours: a case report and review of the literature. Ann R Coll Surg Engl 2014; 96: 96-100.
  13. Osada T, Nagahara A, Kodani T et al. Gastrointestinal stromal tumor of the stomach with a giant abscess penetrating the gastric lumen. World J Gastroenterol 2007; 13: 2385-87.
  14. Maeda Y, Shinohara T, Katayama T et al. Gastrointestinal Stromal Tumor of the Stomach with an Abscess Excised by Laparoscopic Surgery Case Rep. Gastroenterol 2016; 10: 399-405.
  15. Honda K, Mikami T, Ohkusa T et al. Gastrointestinal autonomic nerve tumor with giant abscess. A case report and literature review. J Clin Gastroenterol 1997; 24 (4): 280-5.
  16. Altaca1 G, Demiralay E, Kalayci S.A et al. Giant malignant gastrointestinal stromal tumor presenting as an intraabdominal abscess. J Gastrointestin Liver Dis 2009; 18 (4): 515-6.
  17. Chen H.W, Lin T.Y. Tumor abscess formation caused by Morganella morganii complicated with bacteremia in a patient with gastrointestinal stromal tumor. Clin Res Hepatol Gastroenterol 2012; 36 (2): 29-31.
  18. Lee J.H, Moon J.Y, Kim H.J et al. A Case of a Gastric Gastrointestinal Stromal Tumor with a Fistula and Gastrointestinal Bleeding. Korean J Gastrointest Endosc 2007; 35: 337-41.
  19. Singhal T, Doddi S, Leake T et al. Upper gastrointestinal bleeding due to gastric stromal tumour: a case report. Cases J 2010; 3 (58): 1-7.
  20. Takeuchi N, Nishida Y, Nomura Y et al. A case of bleeding giant gastrointestinal stromal tumor of the stomach who achieved partial response by chemotherapy. GanTo Kagaku Ryoho 2012; 39 (2): 281-4.
  21. Roy S.D, Khan D, De K.K, De U. Spontaneous perforation of jejunal gastrointestinal stromal tumour (gist). Case report and review of literature. W J Emergency Surg 2012; 7: 37.
  22. Alessiani M, Gianola M, Rossi S et al. Peritonitis secondary to spontaneous perforation of a primary gastrointestinal stromal tumour of the small intestine: A case report and a literature review. Int J Surg Case Reports 2015; 6: 58-62.
  23. Yamashita D, Usami Y, Toyosawa S et al. A case of diffuse infiltrating gastrointestinal stromal tumor of sigmoid colon with perforation. Pathol Int 2014; 64 (1): 34-8.
  24. Hohenberger P, Ronellenfitsch U, Oladeji O et al. Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour. Br J Surg 2010; 97: 1854-9.
  25. Steigen S.E, Bjerkehagen B, Haugland H.K. et al. Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway. Mod Pathol 2008; 21: 46-53.
  26. Misawa S, Takeda M, Sakamoto H et al. Spontaneous rupture of a giant gastrointestinal stromal tumor of the jejunum: a case report and literature review. W J Surg Oncol 2014; 12: 153.

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