Long-term effects of pediatric cancer therapy: 35-year clinical experience


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Successes in pediatric cancer treatment made us reassesses treatment goals in favor of maximal anti-cancer effect and decrease unfavorable long-term effects of treatment. Anthracycline antibiotics, platin-derived drugs, methotrexate, bleomycine, irradiated therapy - just a few agents course serious long-term effects for child vital organs and systems after anti-cancer treatment. In the current article international and authors experience in generalysis analysis of anti-cancer treatment long-term effects are presented. Authors present different cardiovascular, respiratory, digestive, endocrine, musculoskeletal immune systems disorders in 873 pediatric cancer survivors. Follow up period from 1979 to 2014 revealed second tumors in this cohort. High value data about health index of pediatric cancer survivors generation, which was comparable with general population.

作者简介

G Zaeva

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

канд. мед. наук, вед. науч. сотр. научно-консультативного отд-ния НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

T Valiev

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

Email: timurvaliev@mail.ru
д-р мед. наук, ст. науч. сотр. отд-ния химиотерапии гемобластозов НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

T Gavrilenko

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

врач научно-консультативного отд-ния НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

E Moiseenko

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

д-р мед. наук, вед. науч. сотр. научно-консультативного отд-ния НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

E Medvedovskaya

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

врач НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

S Mikhailova

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

зав. научно-консультативным отд-нием НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

Yu Sinyagina

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

канд. мед. наук, врач научно-консультативного отд-ния НИИ детской онкологии и гематологии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

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