Alopecia prevention during chemotherapy: from the benchmark to real clinical practice. A prospective study
- 作者: Lyadova M.1,2, Nersesova T.1, Zhuravleva A.1, Fedorinov D.1,3, Dudnik A.1, Denisova E.1, Nosova M.1, Pardabekova O.1, Lisitsyna K.1, Tuleiko V.1, Bikmurzina O.1
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隶属关系:
- Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
- Novokuznetsk State Institute for Further Training of Physicians – branch of the Russian Medical Academy of Continuous Professional Education
- Russian Medical Academy of Continuous Professional Education
- 期: 卷 25, 编号 4 (2023)
- 页面: 498-503
- 栏目: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/252442
- DOI: https://doi.org/10.26442/18151434.2023.4.202454
- ID: 252442
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Background. Alopecia is one of the main side effects of anticancer chemotherapy and has a significant impact on patients’ appearance, quality of life, social adaptation and mental health of cancer patients. Estimated number of new cancer diagnosis increases annually alongside with the proportion of patients receiving chemotherapy. That means an annual increase in the global burden of chemo-induced alopecia and associated negative consequences. The development of various methods for the prevention of alopecia in cancer patients has continued for decades. However, convincing data have been obtained only for the scalp hypothermia method. In this point, the Paxman company’s cooling systems (UK) – the Orbis and Orbis II devices – have been most widely studied. Despite the fact that Orbis devices were approved in Russia more than 10 years ago, since then just a small amount of real clinical practice has been accumulated and questions regarding the effectiveness of scalp hypothermia in patients with variable cancers still remain open.
Aim. Analysis of local clinical practice with scalp hypothermia via the Orbis II device for the prevention of alopecia in patients receiving various chemotherapy regimens.
Materials and methods. An open, prospective, single-center study included patients with various cancer types who were indicated for chemotherapy. Orbis II device was used for prophylactic hypothermia. The severity of alopecia was assessed according to the CTCAE version 5.0 at baseline and during anticancer therapy.
Results. From June 2022 to May 2023, scalp cooling procedures were performed in 51 patients, of them 78% of all procedures were performed in female cancers: breast tumors – 109 (52.2%) procedures, ovarian cancer– 33 (15.8%), and cervix cancer – 22 (10.5%). The effectiveness of scalp hypothermia in preventing of severe alopecia was 73%.
Conclusion. Scalp cooling can be considered as an effective method for the prevention of chemotherapy induced alopecia. Further studies are needed to assess larger patient populations to identify favorable and negative factors that affect potency of the hypothermia.
作者简介
Marina Lyadova
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”; Novokuznetsk State Institute for Further Training of Physicians – branch of the Russian Medical Academy of Continuous Professional Education
编辑信件的主要联系方式.
Email: dr.lyadova@gmail.com
ORCID iD: 0000-0002-9558-5579
SPIN 代码: 8220-2854
Cand. Sci. (Med.)
俄罗斯联邦, Moscow; NovokuznetskTatiana Nersesova
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0000-0002-7853-0349
oncologist
俄罗斯联邦, MoscowAnastasia Zhuravleva
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0009-8951-9792
Treatment Nurse
俄罗斯联邦, MoscowDenis Fedorinov
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”; Russian Medical Academy of Continuous Professional Education
Email: dr.lyadova@gmail.com
ORCID iD: 0000-0001-5516-7367
SPIN 代码: 1079-8460
oncologist
俄罗斯联邦, Moscow; MoscowAnna Dudnik
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0004-7006-7873
Senior Nurse
俄罗斯联邦, MoscowElena Denisova
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0006-9776-9124
Senior Nurse
俄罗斯联邦, MoscowMargarita Nosova
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0003-0622-2528
oncologist
俄罗斯联邦, MoscowOlesya Pardabekova
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0000-0001-5610-4595
oncologist
俄罗斯联邦, MoscowKristina Lisitsyna
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0002-6817-4907
oncologist
俄罗斯联邦, MoscowVeronika Tuleiko
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0001-4913-7601
oncologist
俄罗斯联邦, MoscowOlesya Bikmurzina
Moscow State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare”
Email: dr.lyadova@gmail.com
ORCID iD: 0009-0004-6671-9234
Hospital Nurse
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