Real-world efficacy of the first line therapy with prolgolimab in patients with metastatic melanoma: interim results of the FORA (FOrteca Real practice Assessment) observational study
- 作者: Orlova K.1, Fedyanin M.1,2,3, Simanenkov K.4, Dergunov A.5, Goldshmidt P.6, Saydullaeva A.5, Bogacheva D.7, Yavorskaya M.8, Azanov A.9, Fedenko A.10, Bolotina L.10, Deshkina T.10, Babina K.11, Kuzevanova E.12, Zhukova L.13, Feoktistova P.13, Polshina N.13, Peganova E.14, Shikina V.15, Sobolev M.16, Mironov O.17, Vaschenko V.18, Ershova M.19, Mezhueva A.2, Orlova S.20, Tantsyrev D.21, Taskina D.22, Teterich A.23, Karabina E.24, Kostalanova Y.25, Bogacheva M.26, Zhukova N.27,28, Orlova R.28, Zinkevich M.29, Kazmin A.7, Volkonskiy M.30, Voronkova L.31, Karpova A.32, Maleyko M.33, Gorshenina M.34, Kryuchkova E.35, Moiseenko F.36, Murzina Y.37, Musin S.38, Ogloblin A.39, Perminova M.9, Dumbrava R.40, Emelyanov S.41, Protsenko S.42, Sultanbaev A.38, Tarasova A.25, Shakhnovich E.43, Demchenkova M.44, Lozovskaya Y.45, Musaeva K.46, Pavlova E.47, Skotnikov R.24, Chernova V.48, Chichkanova A.49, Akhmatova A.50, Zafirova M.19, Mischenko A.40, Ovsienko E.41, Petrukhnenko V.51, Syusyukaylova O.52, Tyugina Y.53, Shumilkina E.20, Stroyakovskiy D.30, Yurchenkov A.30, Baldin P.54, Belova A.55, Diduk O.56, Konovalova E.57, Lebedeva L.58, Li Y.59, Mashtapa V.45, Mironenkova Y.47, Narovenkova K.60, Pavlikova O.34, Parsadanova E.61, Pimonova I.62, Ruzhnikova A.58, Sivunova I.63, Soloveva E.58, Sosnin M.64, Temirsultanova T.46, Tyulegenova M.65, Khodkevich A.60, Shakurova N.66, Efendieva S.67, Avagimyan K.45, Anokhina E.68, Antoshkina M.69, Borzyanitsa S.9, Dzhentemirov S.70, Dmitrochenko M.35, Zheleznyak A.49, Komoza Y.60, Kopanev A.71, Kornienko T.17, Krasilnikova M.9, Lukhmanova D.68, Mazur N.19, Markina P.49, Mitapov Z.72, Osodoeva S.72, Prokopenko I.45, Radyukova I.73, Ramazanova M.71, Safarova A.74, Safronova M.35, Khabrieva K.75, Tsygankova N.35, Chermakova K.45, Chirkova T.76, Samoylenko I.1, Nazarova V.1, Akhmetyanova A.1, Demidov L.1
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隶属关系:
- Blokhin National Medical Research Center of Oncology
- Moscow Multidisciplinary Clinical Center “Kommunarka“
- Pirogov National Medical and Surgical Center
- Lipetsk Regional Oncological Dispensary
- Tver Regional Clinical Oncological Dispensary
- Rostov-on-Don Oncological Dispensary
- Voronezh Regional Clinical Oncology Dispensary
- Sochi Oncological Dispensary №2
- Rappoport Kuzbass Clinical Oncological Dispensary
- Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre
- Volgograd Regional Clinical Oncological Dispensary
- Saratov Regional Clinical Oncological Dispensary
- Loginov Moscow Clinical Scientific Center
- Yaroslavl Clinical Oncology Hospital
- Vladimirsky Moscow Regional Research Clinical Institute
- City Clinical Oncology Hospital №1
- Tambov Regional Oncological Clinical Dispensary
- Kostroma Oncological Dispensary
- Sverdlovsk Regional Oncological Dispensary
- Cheboksary Republican Clinical Oncological Dispensary
- Altai Regional Oncological Dispensary
- Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
- Belgorod Regional Oncological Dispensary
- Tula Regional Clinical Oncological Dispensary
- Samara Regional Clinical Oncology Dispensary
- Vologda Regional Clinical Hospital №2
- Saint Petersburg State University
- Saint Petersburg City Clinical Oncology Dispensary
- Leningrad Regional Clinical Oncology Dispensary
- Moscow City Oncological Hospital №62
- Vladikavkaz Republican Oncological Dispensary
- Trans-Baikal Regional Oncological Dispensary
- Shakhty Oncological Dispensary
- Yoshkar-Ola Republican Oncological Dispensary
- Smolensk Regional Oncological Clinical Dispensary
- Saint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology)
- Birobidzhan Oncological Dispensary
- Ufa Republican Clinical Oncology Center
- Oryol Oncological Dispensary
- Primorsky Regional Oncological Dispensary
- Primushko Republican Clinical Oncological Dispensary
- Petrov National Medical Research Center of Oncology
- Korolyov City Hospital
- Irkutsk Regional Oncological Dispensary
- Ostroverkhov Kursk Cancer Research and Clinical Center
- Oncology Center “AiMed”
- Vologda Regional Oncological Dispensary
- Ryazan Regional Clinical Oncological Dispensary
- Nizhny Novgorod Regional Clinical Oncology Center
- Nalchik Oncological Dispensary
- Komsomolsk-on-Amur Oncological Dispensary
- Ashkhamaf Adygei Republican Clinical Oncology Center
- Ivanovo Regional Oncological Dispensary
- Naberezhnye Chelny Oncological Dispensary – branch of the Republican Clinical Oncological Dispensary
- Novgorod Regional Clinical Oncological Dispensary
- Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
- Murmansk Regional Oncological Dispensary
- Arkhangelsk Clinical Oncology Dispensary
- Clinic Lyadov
- Bryansk Regional Oncological Dispensary
- Sakhalin Regional Oncological Dispensary
- Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Center
- Kamchatka Regional Oncology Center
- Krasnogorsk City Hospital №1
- Orenburg Regional Clinical Oncology Dispensary
- Tomsk Regional Oncological Dispensary
- Makhachkala Republican Cancer Center
- Ulyanovsk Regional Clinical Oncology Dispensary
- Saransk Republican Oncological Dispensary
- Stavropol Regional Clinical Oncology Center
- Kirov Center of Oncology and Medical Radiology
- Buryat Republican Clinical Oncological Dispensary
- Omsk Clinical Oncological Dispensary
- Almetyevsk branch of the Republican Clinical Oncological Dispensary
- Republican Oncological Dispensary of the Republic of Ingushetia
- Rappoport Novokuznetsk branch of the Kuzbass Clinical Oncological Dispensary
- 期: 卷 24, 编号 4 (2022)
- 页面: 413-425
- 栏目: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/132974
- DOI: https://doi.org/10.26442/18151434.2022.4.202035
- ID: 132974
如何引用文章
全文:
详细
Background. Novel agents – immune checkpoint inhibitors – fundamentally changed the prognosis for life in patients with metastatic and/or inoperable melanoma. The development, studies, and approval of a new original PD1 inhibitor in Russia in 2020 prompted the professional community to conduct a prospective observational study in the Russian Federation to assess the real-world efficacy and safety of prolgolimab, as real-world patients differ from the refined population in clinical trials.
Aim. To evaluate the real-world efficacy and safety of prolgolimab in patients with metastatic and/or inoperable melanoma.
Materials and methods. From October 2020 to October 2022, the study enrolled 700 patients with metastatic and/or inoperable melanoma receiving prolgolimab in real clinical settings in oncological institutions of various levels in the Russian Federation. The main inclusion criteria were: pathology-confirmed diagnosis of melanoma, metastatic and/or inoperable type, use of prolgolimab outside of clinical trials, and signed informed consent by the patient. Objective response rate (ORR) was considered the main criterion for evaluating the efficacy of therapy, and the safety criterion was the incidence of grade 3–4 adverse events. Statistical analysis was performed using the SPSS 20.0 software package.
Results. The ORR for patients with skin melanoma treated with prolgolimab in the first line therapy (n= 207/337) was 48.3% (n=100), the disease stabilization was reported in 30.4% (n=63), and progression in 21.3% (n=44) of patients. There were no significant differences in response to therapy between patients with/without BRAF mutation, although ORR was higher in patients with BRAF mutation: the ORR for patients with BRAF mutation was 57.9% (n=33), and for BRAF non-mutated patients, 44.4% (n=52; p=0.222). At a median follow-up of 5 months, the median PFS was 10 months (95% confidence interval 7.35–12.64). The incidence of grade 3–4 treatment-related adverse events according to CTCAE 5.0 was 2% (n=12), and 12% (n=82) for grade 1–2 adverse events.
Conclusion. The results confirm the high efficacy and satisfactory tolerability of prolgolimab in patients with metastatic and/or inoperable melanoma in real-world settings. There were no significant differences in ORR between patients with or without BRAF mutation.
作者简介
Kristina Orlova
Blokhin National Medical Research Center of Oncology
编辑信件的主要联系方式.
Email: krisman03@gmail.com
ORCID iD: 0000-0002-0442-5917
Cand. Sci. (Med.)
俄罗斯联邦, MoscowMikhail Fedyanin
Blokhin National Medical Research Center of Oncology; Moscow Multidisciplinary Clinical Center “Kommunarka“; Pirogov National Medical and Surgical Center
Email: krisman03@gmail.com
ORCID iD: 0000-0001-5615-7806
D. Sci. (Med.)
俄罗斯联邦, Moscow; Moscow; MoscowKonstantin Simanenkov
Lipetsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, LipetskAleksandr Dergunov
Tver Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, TverPetr Goldshmidt
Rostov-on-Don Oncological Dispensary
Email: krisman03@gmail.com
Deputy Chief Doctor
俄罗斯联邦, Rostov-on-DonAleksandra Saydullaeva
Tver Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, TverDary Bogacheva
Voronezh Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, VoronezhMarina Yavorskaya
Sochi Oncological Dispensary №2
Email: krisman03@gmail.com
Deputy Chief Doctor
俄罗斯联邦, SochiArtur Azanov
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, KemerovoAlexander Fedenko
Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4927-5585
D. Sci. (Med.)
俄罗斯联邦, MoscowLarisa Bolotina
Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4879-2687
D. Sci. (Med.)
俄罗斯联邦, MoscowTatyana Deshkina
Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, MoscowKseniya Babina
Volgograd Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, VolgogradEkaterina Kuzevanova
Saratov Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, SaratovLiudmila Zhukova
Loginov Moscow Clinical Scientific Center
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4848-6938
D. Sci. (Med.), Corr. Memb. RAS
俄罗斯联邦, MoscowPolina Feoktistova
Loginov Moscow Clinical Scientific Center
Email: krisman03@gmail.com
ORCID iD: 0000-0002-0340-7119
Cand. Sci. (Med.)
俄罗斯联邦, MoscowNatalya Polshina
Loginov Moscow Clinical Scientific Center
Email: krisman03@gmail.com
ORCID iD: 0000-0001-5417-0425
Oncologist
俄罗斯联邦, MoscowEkaterina Peganova
Yaroslavl Clinical Oncology Hospital
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, YaroslavlValentina Shikina
Vladimirsky Moscow Regional Research Clinical Institute
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, MoscowMaksim Sobolev
City Clinical Oncology Hospital №1
Email: krisman03@gmail.com
Chemotherapist
俄罗斯联邦, MoscowOleg Mironov
Tambov Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, TambovVera Vaschenko
Kostroma Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KostromaMariya Ershova
Sverdlovsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, YekaterinburgAgniya Mezhueva
Moscow Multidisciplinary Clinical Center “Kommunarka“
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, MoscowSvetlana Orlova
Cheboksary Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, CheboksaryDenis Tantsyrev
Altai Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
俄罗斯联邦, BarnaulDarya Taskina
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, ChelyabinskAntonina Teterich
Belgorod Regional Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, BelgorodElena Karabina
Tula Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, TulaYuliya Kostalanova
Samara Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, SamaraMarina Bogacheva
Vologda Regional Clinical Hospital №2
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, VologdaNatalia Zhukova
Saint Petersburg State University; Saint Petersburg City Clinical Oncology Dispensary
Email: krisman03@gmail.com
ORCID iD: 0000-0002-0619-2205
Cand. Sci. (Med.)
俄罗斯联邦, Saint Petersburg; Saint PetersburgRashida Orlova
Saint Petersburg City Clinical Oncology Dispensary
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4447-9458
D. Sci. (Med.), Prof.
俄罗斯联邦, Saint PetersburgMaksim Zinkevich
Leningrad Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgAleksandr Kazmin
Voronezh Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, VoronezhMikhail Volkonskiy
Moscow City Oncological Hospital №62
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4060-5015
Head of the Day Hospital
俄罗斯联邦, MoscowLiya Voronkova
Vladikavkaz Republican Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, VladikavkazAnastasiya Karpova
Trans-Baikal Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, ChitaMikhail Maleyko
Shakhty Oncological Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, ShakhtyMariya Gorshenina
Yoshkar-Ola Republican Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, Yoshkar-OlaElena Kryuchkova
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, SmolenskFedor Moiseenko
Saint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology)
Email: krisman03@gmail.com
ORCID iD: 0000-0003-2544-9042
D. Sci. (Med.)
俄罗斯联邦, Saint PetersburgYuliya Murzina
Birobidzhan Oncological Dispensary
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, BirobidzhanShamil Musin
Ufa Republican Clinical Oncology Center
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, UfaAndrey Ogloblin
Oryol Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, OryolMariya Perminova
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KemerovoRegina Dumbrava
Primorsky Regional Oncological Dispensary
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, VladivostokSergey Emelyanov
Primushko Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, IzhevskSvetlana Protsenko
Petrov National Medical Research Center of Oncology
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, Saint PetersburgAlexander Sultanbaev
Ufa Republican Clinical Oncology Center
Email: krisman03@gmail.com
ORCID iD: 0000-0003-0996-5995
Cand. Sci. (Med.)
俄罗斯联邦, UfaAnna Tarasova
Samara Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, SamaraElena Shakhnovich
Korolyov City Hospital
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, KorolyovMarina Demchenkova
Irkutsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, IrkutskYuliya Lozovskaya
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KurskKhedi Musaeva
Oncology Center “AiMed”
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, GroznyElena Pavlova
Vologda Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
俄罗斯联邦, VologdaRoman Skotnikov
Tula Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, TulaVera Chernova
Ryazan Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, RyazanAngelina Chichkanova
Nizhny Novgorod Regional Clinical Oncology Center
Email: krisman03@gmail.com
Head of the Day Hospital
俄罗斯联邦, Nizhny NovgorodAdina Akhmatova
Nalchik Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, NalchikMarina Zafirova
Sverdlovsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of Chemotherapy Service
俄罗斯联邦, YekaterinburgAndrey Mischenko
Primorsky Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
俄罗斯联邦, VladivostokElena Ovsienko
Primushko Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, IzhevskViktoriya Petrukhnenko
Komsomolsk-on-Amur Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, Komsomolsk-on-AmurOksana Syusyukaylova
Ashkhamaf Adygei Republican Clinical Oncology Center
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, MaykopYana Tyugina
Ivanovo Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, IvanovoElena Shumilkina
Cheboksary Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, CheboksaryDaniil Stroyakovskiy
Moscow City Oncological Hospital №62
Email: krisman03@gmail.com
ORCID iD: 0000-0003-1973-1092
Cand. Sci. (Med.)
俄罗斯联邦, MoscowAleksandr Yurchenkov
Moscow City Oncological Hospital №62
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, MoscowPavel Baldin
Naberezhnye Chelny Oncological Dispensary – branch of the Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, Naberezhnye ChelnyAnastasiya Belova
Novgorod Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, Veliky NovgorodOlga Diduk
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KrasnoyarskElena Konovalova
Murmansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, MurmanskLyudmila Lebedeva
Arkhangelsk Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, ArkhangelskYaroslav Li
Clinic Lyadov
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KhimkiViktoriya Mashtapa
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KurskYana Mironenkova
Vologda Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, VologdaKristina Narovenkova
Bryansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, BryanskOlga Pavlikova
Yoshkar-Ola Republican Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, Yoshkar-OlaElvira Parsadanova
Sakhalin Regional Oncological Dispensary
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, Yuzhno-SakhalinskIrina Pimonova
Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Center
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, ObninskAnna Ruzhnikova
Arkhangelsk Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, ArkhangelskIrina Sivunova
Kamchatka Regional Oncology Center
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, Petropavlovsk-KamchatskyEkaterina Soloveva
Arkhangelsk Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
俄罗斯联邦, ArkhangelskMaksim Sosnin
Krasnogorsk City Hospital №1
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KrasnogorskToita Temirsultanova
Oncology Center “AiMed”
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, GroznyMakhabbat Tyulegenova
Orenburg Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
俄罗斯联邦, OrenburgAleksandra Khodkevich
Bryansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, BryanskNadezhda Shakurova
Tomsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, TomskSureya Efendieva
Makhachkala Republican Cancer Center
Email: krisman03@gmail.com
Deputy Chief Doctor
俄罗斯联邦, MakhachkalaKarine Avagimyan
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KurskEkaterina Anokhina
Ulyanovsk Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, UlyanovskMariya Antoshkina
Saransk Republican Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, SaranskStanislav Borzyanitsa
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, KemerovoSamir Dzhentemirov
Stavropol Regional Clinical Oncology Center
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, StavropolMarina Dmitrochenko
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, SmolenskAlla Zheleznyak
Nizhny Novgorod Regional Clinical Oncology Center
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, Nizhny NovgorodYuliya Komoza
Bryansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, BryanskAleksandr Kopanev
Kirov Center of Oncology and Medical Radiology
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KirovTatyana Kornienko
Tambov Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, TambovMargarita Krasilnikova
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
俄罗斯联邦, KemerovoDarya Lukhmanova
Ulyanovsk Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, UlyanovskNatalya Mazur
Sverdlovsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, YekaterinburgPolina Markina
Nizhny Novgorod Regional Clinical Oncology Center
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, Nizhny NovgorodZhargal Mitapov
Buryat Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, Ulan-UdeSvetlana Osodoeva
Buryat Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, Ulan-UdeIrina Prokopenko
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, KurskIrina Radyukova
Omsk Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, OmskMadina Ramazanova
Kirov Center of Oncology and Medical Radiology
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, KirovAlfiya Safarova
Almetyevsk branch of the Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Сhemotherapist
俄罗斯联邦, AlmetyevskMariya Safronova
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, SmolenskKhalimat Khabrieva
Republican Oncological Dispensary of the Republic of Ingushetia
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, NazranNatalya Tsygankova
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, SmolenskKseniya Chermakova
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
俄罗斯联邦, KurskTatyana Chirkova
Rappoport Novokuznetsk branch of the Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
俄罗斯联邦, NovokuznetskIgor Samoylenko
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0001-7150-5071
Cand. Sci. (Med.)
俄罗斯联邦, MoscowValeria Nazarova
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0003-0532-6061
Cand. Sci. (Med.)
俄罗斯联邦, MoscowAngelina Akhmetyanova
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
Graduate Student
俄罗斯联邦, MoscowLev Demidov
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0002-8562-6082
D. Sci. (Med.), Prof.
俄罗斯联邦, Moscow参考
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- Строяковский Д.Л., Абрамов М.Е., Демидов Л.В., и др. Практические рекомендации по лекарственному лечению меланомы кожи. Злокачественные опухоли. 2020;10(3s2-1):267-82 [Stroyakovskii DL, Abramov MIe, Demidov LV, et al. Prakticheskiie rekomendatsii po lekarstvennomu lecheniiu melanomy kozhi. Zlokachestvennyie opukholi. 2020;10(3s2-1):267-82 (in Russian)]. doi: 10.18027/2224-5057-2020-10-3s2-16
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- Tjulandin S, Demidov L, Moiseyenko V, et al. Novel PD-1 inhibitor prolgolimab: expanding non-resectable/metastatic melanoma therapy choice. Eur J Cancer. 2021;149:222-32. doi: 10.1016/j.ejca.2021.02.030
- Donia M, Kimper-Karl ML, Høyer KL, et al. The majority of patients with metastatic melanoma are not represented in pivotal phase III immunotherapy trials. Eur J Cancer. 2017;74:89-95. doi: 10.1016/j.ejca.2016.12.017
- Hodi FS, O’Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-23. doi: 10.1056/NEJMoa1003466
- Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517-26. doi: 10.1056/NEJMoa1104621
- Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320-30. doi: 10.1056/NEJMoa1412082
- Robert C, Schachter J, Long GV, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372(26):2521-32. DOI:NEJMoa1503093
- Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined nivolumab and ipilimumab or mono- therapy in untreated melanoma. N Engl J Med. 2015;373(1):23-34. doi: 10.1056/NEJMoa1504030
- Real-World Evidence. Available at: https://www.fda.gov/science-research/science-and-research-special-topics/real-world-evidence. Accessed: 11.11.2022.
- Multicenter Study of Safety and Efficacy of Prolgolimab in Patients With Advanced Melanoma in Routine Clinical Practice (FORA). Available at: https://clinicaltrials.gov/ct2/show/NCT05120024?term=prolgolimab&draw=2&rank=1. Accessed: 11.11.2022.
- Kuzmanovszki D, Kiss N, Toth B, et al. Anti-PD-1 Monotherapy in Advanced Melanoma-Real-World Data from a 77-Month-Long Retrospective Observational Study. Biomedicines. 2022;10(7):1737. doi: 10.3390/biomedicines10071737
- Mohr P, Scherrer E, Assaf C, et al. Real-World Therapy with Pembrolizumab: Outcomes and Surrogate Endpoints for Predicting Survival in Advanced Melanoma Patients in Germany. Cancers. 2022;14(7):1804. doi: 10.3390/cancers14071804
- Monestier S, Dalle S, Mortier L, et al .Effectiveness and safety of nivolumab in patients with advanced melanoma: A multicenter, observational study. Int J Cancer. 2021;148(11):2789-98. doi: 10.1002/ijc.33467
- Frank GA, Aleksakhina SN, Zavalishina LE, et al. BRAF and NRAS mutations in Russian melanoma patients: results of a nationwide study. Melanoma Res. 2016;26(5):442-7. doi: 10.1097/CMR.0000000000000278
- Wolchok JD, Chiarion-Sileni V, Gonzalez R, et al. Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma. J Clin Oncol. 2022;40(2):127-37. doi: 10.1200/JCO.21.02229