The role of molecular genetic factors in the development of cholangiocellular cancer: A review
- 作者: Chulkova S.1,2, Loginov V.3, Podluzhny D.1, Egorova A.2, Semichev D.2, Gladilina I.1,2, Kudashkin N.1,2
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隶属关系:
- Blokhin National Medical Research Center of Oncology
- Pirogov Russian National Research Medical University
- Research Institute of General Pathology and Pathophysiology
- 期: 卷 24, 编号 2 (2022)
- 页面: 164-168
- 栏目: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/109338
- DOI: https://doi.org/10.26442/18151434.2022.2.201426
- ID: 109338
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This article highlights the main inducers of cholangiocarcinogenesis. Data are presented on the study of gene mutations, the variations of which depending on the localization of biliary cancer may be different (FGFR2 – in intrahepatic PRKACA, PRKACB – cholangiocarcinoma in extrahepatic cholangiocarcinoma). Mutations in the KRAS, TP53, ARIAD1A genes are common in extrahepatic bile duct cancer. Epigenetic events such as DNA hypermethylation, histone modifications, chromatin remodeling, and disturbances in miRNA expression are considered. A number of epigenetic features, such as the presence of a TP53 gene mutation with hypermethylation of p14ARF, DAPK, and/or ASC, correlate with a more aggressive course of the disease. The role of the SOX17 gene in the development of drug resistance is highlighted. The study of molecular genetic features of extrahepatic bile duct cancer is an important aspect in understanding the pathogenesis of this type of tumor, reveals new prognostic and diagnostic markers of the disease. It is possible that in the future, as knowledge is accumulated, this will make it possible to individualize approaches to the treatment of this category of patients.
作者简介
Svetlana Chulkova
Blokhin National Medical Research Center of Oncology; Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: chulkova@mail.ru
ORCID iD: 0000-0003-4412-5019
Cand. Sci. (Med.)
俄罗斯联邦, Moscow; MoscowVitaly Loginov
Research Institute of General Pathology and Pathophysiology
Email: werwolf2000@mail.ru
Cand. Sci. (Biol.)
俄罗斯联邦, MoscowDanil Podluzhny
Blokhin National Medical Research Center of Oncology
Email: danil-p@mail.ru
ORCID iD: 0000-0001-7375-3378
Cand. Sci. (Med.)
俄罗斯联邦, MoscowAngelina Egorova
Pirogov Russian National Research Medical University
Email: sapphir5@mail.ru
ORCID iD: 0000-0003-3904-8530
Cand. Sci. (Med.), Prof.
俄罗斯联邦, MoscowDmitry Semichev
Pirogov Russian National Research Medical University
Email: dsemichev71@mail.ru
ORCID iD: 0000-0001-6148-8933
Resident
俄罗斯联邦, MoscowIrina Gladilina
Blokhin National Medical Research Center of Oncology; Pirogov Russian National Research Medical University
Email: 0152@mail.ru
ORCID iD: 0000-0002-2481-0791
D. Sci. (Med.)
俄罗斯联邦, Moscow; MoscowNikolai Kudashkin
Blokhin National Medical Research Center of Oncology; Pirogov Russian National Research Medical University
Email: dr.kudashkin@mail.ru
Cand. Sci. (Med.)
俄罗斯联邦, Moscow; Moscow参考
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