The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis
- 作者: Nasretdinov A.1, Menshikov K.1,2, Sultanbaev A.1, Musin S.1,2, Sultanbaeva N.1, Men'shikova I.2
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隶属关系:
- Republican Clinical Oncological Dispensary
- Bashkir State Medical University
- 期: 卷 24, 编号 3 (2022)
- 页面: 340-344
- 栏目: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/105003
- DOI: https://doi.org/10.26442/18151434.2022.3.201813
- ID: 105003
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详细
Knowledge of the molecular characteristics of the progression of non-small cell lung tumors currently provides the patient with the best treatment options. One of the most well-known and studied genetic abnormalities is a mutation in the EGFR gene, which makes the tumor sensitive to therapy with tyrosine kinase inhibitors. In the conditions of the existence of several therapeutic options at once, it is required to know not only the results of clinical trials, but also the fundamental features of the mechanisms of action of a particular drug. The article contains a literature review, presenting the features of the functioning of EGFR (epidermal growth factor receptor), the mechanisms of action of EGFR inhibitors of different generations (erlotinib, gefitinib, afatinib, osimertinib), generalization and analysis of the main differences between them.
作者简介
Ainur Nasretdinov
Republican Clinical Oncological Dispensary
编辑信件的主要联系方式.
Email: rkodrb@yandex.ru
ORCID iD: 0000-0001-8340-7962
oncologist
俄罗斯联邦, UfaKonstantin Menshikov
Republican Clinical Oncological Dispensary; Bashkir State Medical University
Email: kmenshikov80@bk.ru
ORCID iD: 0000-0003-3734-2779
Cand. Sci. (Med.)
俄罗斯联邦, Ufa; UfaAlexander Sultanbaev
Republican Clinical Oncological Dispensary
Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-0996-5995
Cand. Sci. (Med.)
俄罗斯联邦, UfaShamil Musin
Republican Clinical Oncological Dispensary; Bashkir State Medical University
Email: musin_shamil@mail.ru
ORCID iD: 0000-0003-1185-977X
Cand. Sci. (Med.)
俄罗斯联邦, Ufa; UfaNadezda Sultanbaeva
Republican Clinical Oncological Dispensary
Email: nd.sultan@rambler.ru
ORCID iD: 0000-0001-5926-0446
oncologist
俄罗斯联邦, UfaIrina Men'shikova
Bashkir State Medical University
Email: i-menshikova@bk.ru
ORCID iD: 0000-0002-8665-8895
Cand. Sci. (Med.), Assoc. Prof.
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