Место двойной иммунологической блокады в лечении метастатического немелкоклеточного рака легкого: реальность и перспективы

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Аннотация

В настоящее время иммунотерапия является ключевой опцией в лекарственном лечении немелкоклеточного рака легкого. Перед онкологами в реальной клинической практике стоит непростой выбор 1-й линии терапии от моноиммунотерапии до различных комбинированных режимов, включая двойную иммунологическую блокаду PD-1/PD-L1 и CTLA-4. Цель данного обзора – попытка уточнить место двойной иммунологической блокады среди других режимов комбинированного лечения немелкоклеточного рака легкого в настоящее время и возможные перспективы. Позитивные ожидания от двойной иммунотерапии связаны с предположением, что комбинированное использование этих препаратов является синергетическим и может помочь преодолеть резистентность к терапии одним препаратом. В обзоре собрана информация из открытых источников как о текущих исследованиях с двойной иммунологической блокадой, так и о уже полученных результатах по применению комбинации ниволумаба и ипилимумаба, тремелимумаба и дурвалумаба и других препаратов для лечения пациентов с метастатическим немелкоклеточным раком легкого. Использование данного подхода представляется перспективным для возможного преодоления резистентности к моноиммунотерапии анти-PD1/PD-L1-препаратами, особенно в популяции пациентов с низким и негативным PD-L1-статусом.

Об авторах

Денис Иванович Юдин

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России

Автор, ответственный за переписку.
Email: yudinden@mail.ru
ORCID iD: 0000-0002-0620-2696

канд. мед. наук, ст. науч. сотр. отд-ния лекарственных методов лечения (химиотерапевтическое) №17

Россия, Москва

Константин Константинович Лактионов

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России

Email: lkoskos@mail.ru
ORCID iD: 0000-0003-4469-502X

д-р мед. наук, проф. каф. онкологии и лучевой терапии лечебного фак-та, зав. онкологическим отд-нием лекарственных методов лечения (химиотерапевтическое) №17

Россия, Москва

Людмила Валентиновна Лактионова

ЗАО «МЦК»

Email: laktionova@list.ru
ORCID iD: 0000-0002-5749-9864

д-р мед. наук

Россия, Москва

Валерий Владимирович Бредер

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России

Email: vbreder@yandex.ru
ORCID iD: 0000-0002-6244-4294

д-р мед. наук, вед. науч. сотр.

Россия, Москва

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